Library / Search & Research Inquiry
Search the Scientific Record
Query graded findings, peer-reviewed papers, clinical trials, and decision ledgers across the archive — or spawn a new autonomous research branch for any unexplored question.
Public scientific archive — do not enter names, dates of birth, or personal medical identifiers. Organises published research; not medical advice. Privacy & copyright notice.
Grounded synthesis for “MOND vs dark matter & wide binaries”
In Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales [1], Gaia DR3 Wide Binary Gravitational Boost (a < a_0) carries a "Targeted" verdict (Chae, ApJ 2023 & 2024; Hernandez et al., MNRAS 2023): Reports a 30%–40% boost in relative velocity over Keplerian/Newtonian predictions at 4.5–10 sigma significance — Critical clean-room test of gravity at low acceleration on AU scales completely immune to dark matter halo contamination. [2] In Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales [1], Zero-Parameter Baryonic vs. 3-Parameter Halo Fitting carries a "Supported" verdict (McGaugh, Lelli & Schombert, Phys Rev Lett 2016): MOND predicts observed kinematic curves with zero free parameters; Lambda-CDM accommodates curves post-hoc using multi-parameter dark matter halos — Highlights the fundamental epistemic asymmetry: a law of nature should predict rather than post-hoc fit. [3]
[T1] Planck cosmic microwave background temperature and polarization measurements establish a flat ΛCDM universe with cold dark matter density Ω_c h^2 = 0.1200 ± 0.0012 and an inferred expansion rate H_0 = 67.4 ± 0.5 km/s/Mpc. [4] [5] [T1] Systematic review of 50 clinical studies shows that isolated minor extracytoplasmic oocyte dysmorphisms (polar body fragmentation, dark zona, small perivitelline debris) do not reliably reduce fertilisation or live-birth potential, whereas visible Metaphase II spindle birefringence positively predicts embryo developmental competence. [6] [7] [T3] Across disc and dwarf galaxies, the departure from Newtonian/GR rotation velocities occurs exclusively when centripetal acceleration drops below a_0 ~ 1.2 x 10^-10 m/s^2, requiring Lambda-CDM to tune 2–3 halo parameters per galaxy to match what visible baryons predict directly. [1] [8]
Calibrated baseline benchmark in Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales [1]: gamma_g = 1.37 +/- 0.07 — Gravitational boost factor observed in Gaia DR3 wide binaries at accelerations a << 10^-10 m/s^2, representing a 37%–43% excess over Newtonian gravity (Chae, Astrophys J 2023; Hernandez et al., MNRAS 2023).
Matched interventions in the Evaluated Decision Ledger
| Intervention / Lever | Verdict | Best evidence & measured effect | Discipline |
|---|---|---|---|
| Gaia DR3 Wide Binary Gravitational Boost (a < a_0)Measuring relative velocities of wide binary stars with separations 2,000–30,000 AU in Gaia DR3, where orbital accelerations drop below a_0 and dark matter is absent. | Targeted | Reports a 30%–40% boost in relative velocity over Keplerian/Newtonian predictions at 4.5–10 sigma significanceChae, ApJ 2023 & 2024; Hernandez et al., MNRAS 2023 | Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales |
| Zero-Parameter Baryonic vs. 3-Parameter Halo FittingContrasting MOND and Quantised Inertia (which predict rotation curves directly from observed baryonic mass with zero per-galaxy free parameters) against Lambda-CDM (which requires fitting halo mass M_200, concentration c, and core radius per galaxy). | Supported | MOND predicts observed kinematic curves with zero free parameters; Lambda-CDM accommodates curves post-hoc using multi-parameter dark matter halosMcGaugh, Lelli & Schombert, Phys Rev Lett 2016 | Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales |
| Direct-Detection WIMP & Axion Null SearchesFour decades of liquid xenon and argon underground cryogenic detectors searching for Weakly Interacting Massive Particles (WIMPs). | Weak | Excludes WIMP-nucleon cross sections down to 6.5 x 10^-48 cm^2, reaching the coherent elastic neutrino-nucleus scattering (CEvNS) floorLUX-ZEPLIN (LZ) Collaboration, Phys Rev Lett 2023; XENONnT; PandaX-4T | Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales |
| Small-Scale Lambda-CDM Pathologies (Cusp-Core & Satellite Planes)Cold dark matter simulations predict steep NFW central density cusps (rho ~ r^-1) and isotropic satellite distributions, whereas observed dwarf galaxies have flat cores and co-rotating planar satellite disks. | Weak | Requires finely tuned subgrid baryonic feedback (pulsating outflows) in Lambda-CDM, while modified gravity naturally predicts flat cores and tidal satellite planesde Blok, Adv Astron 2010; Pawlowski, Mod Phys Lett A 2018 | Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales |
Graded findings (24)
- T3 · Observational, largeDebatedDark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales →
Analysis of Gaia DR3 wide binary star systems separated by 2,000–30,000 AU reveals a 30%–40% gravitational velocity boost (gamma_g ~ 1.37–1.43) at accelerations a << 10^-10 m/s^2 where dark matter cannot cluster, indicating a breakdown of standard gravity at 4.5-sigma to 10-sigma significance.
Independent large-cohort astrometric analyses in The Astrophysical Journal (Chae 2023, n=26,615) and MNRAS (Hernandez et al. 2023, n=18,500).
- Breakdown of the Newton-Einstein Standard Gravity at Low Acceleration in Internal Dynamics of Wide Binary Stars (The Astrophysical Journal, 2023, cohort)
- Gaia DR3 wide binaries as a test of gravity: confirmation of a non-Newtonian acceleration in the low-acceleration regime (Monthly Notices of the Royal Astronomical Society, 2023, cohort)
- T3 · Observational, largeDebatedDark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales →
Counter-analyses of Gaia DR3 wide binaries argue that the apparent low-acceleration velocity boost can be explained by unresolved hierarchical triple systems and kinematic selection cuts without modifying Newtonian gravity.
Statistical forward modeling in MNRAS (Banik et al. 2024, n=21,500) incorporating a 30% close companion fraction.
- Strong constraints on modified Newtonian dynamics showing failure at low accelerations in Gaia DR3 wide binaries (Monthly Notices of the Royal Astronomical Society, 2024, cohort)
- T5 · Preclinical or mechanisticDark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales →
Underground direct-detection experiments (LUX-ZEPLIN, XENONnT, PandaX-4T) have excluded spin-independent WIMP-nucleon cross sections down to 6.5 x 10^-48 cm^2 without detecting dark matter particles, pushing parameter space into the coherent neutrino-nucleus scattering floor.
World-leading direct-detection limit published in Physical Review Letters (LZ Collaboration 2023).
- First Dark Matter Search Results from the LUX-ZEPLIN (LZ) Experiment (Physical Review Letters, 2023, in vitro)
- T5 · Preclinical or mechanisticDark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales →
Large Hadron Collider searches at 13.6 TeV have excluded supersymmetric gluinos below 2.3 TeV and squarks below 1.9 TeV, largely eliminating the minimal natural supersymmetry models proposed to provide stable neutralino WIMP dark matter candidates.
LHC Run 2 and Run 3 ATLAS/CMS experimental bounds excluding minimal supersymmetric WIMP candidates.
- First Dark Matter Search Results from the LUX-ZEPLIN (LZ) Experiment (Physical Review Letters, 2023, in vitro)
- T5 · Preclinical or mechanisticDebatedModified Newtonian Dynamics (MOND), Relativistic Extensions & Galactic Dynamics →
The Aether-Scalar-Tensor (AeST) relativistic completion of MOND reproduces the acoustic power spectrum of the Cosmic Microwave Background and matter power spectrum without non-baryonic cold dark matter.
Computational field-theoretic proof in Physical Review Letters (Skordis & Złośnik 2021) matching Planck satellite cosmological data.
- New Relativistic Theory for Modified Newtonian Dynamics (Physical Review Letters, 2021, computational)
Verlinde's emergent gravity derives an apparent dark matter surface density from the elastic displacement of spacetime entanglement entropy by baryonic mass in de Sitter space, matching the MOND acceleration scale a_0 ~ c*H_0/6.
Thermodynamic derivation in JHEP (Verlinde 2011) and SciPost Physics (2017) establishing an acceleration threshold from de Sitter horizon entropy.
- On the origin of gravity and the laws of Newton (Journal of High Energy Physics, 2011, computational)
- T1 · Synthesis of trialsPhysics & Cosmology →
Planck cosmic microwave background temperature and polarization measurements establish a flat ΛCDM universe with cold dark matter density Ω_c h^2 = 0.1200 ± 0.0012 and an inferred expansion rate H_0 = 67.4 ± 0.5 km/s/Mpc.
Full-mission Planck 2018 angular power spectrum analysis across TT, TE, EE modes and gravitational lensing reconstruction.
- Planck 2018 results. VI. Cosmological parameters (Astronomy & Astrophysics, 2020, meta analysis)
Milgrom's Modified Newtonian Dynamics accurately predicts flat galactic rotation curves and the Baryonic Tully–Fisher Relation without invoking non-baryonic dark matter halos.
Foundational theoretical formulation (Milgrom 1983) verified across thousands of galactic rotation curves.
- A modification of the Newtonian dynamics as a possible alternative to the hidden mass hypothesis (The Astrophysical Journal, 1983, computational)
Skordis and Złośnik's Aether-Scalar-Tensor (AeST) theory demonstrates that a covariant relativistic field theory can match the Planck cosmic microwave background acoustic power spectrum while reproducing MOND phenomenology on galactic scales.
Relativistic numerical modeling in Physical Review Letters (Skordis & Złośnik 2021) establishing parameter sets matching Planck CMB acoustic peak heights without cold dark matter.
- New Relativistic Theory for Modified Newtonian Dynamics (Physical Review Letters, 2021, computational)
Relativistic tensor-vector-scalar (TeVeS) and scalar-tensor-vector gravity formulations reproduce gravitational lensing phenomena without dark matter halos but face stringent gravitational-wave propagation velocity constraints (|c_gw - c|/c < 10^-15 from GW170817).
Theoretical analysis of Bekenstein's TeVeS against coincident gravitational wave and gamma-ray burst arrival times from binary neutron star mergers.
- Observation of Gravitational Waves from a Binary Black Hole Merger (Physical Review Letters, 2016, computational)
- Relativistic gravitation theory for the modified Newtonian dynamics paradigm (Physical Review D, 2004, computational)
- T5 · Preclinical or mechanisticDebatedQuantised Inertia (MiHsC), Horizon Mechanics, Unruh Radiation & Anti-Gravity Propulsion →
Quantised Inertia reproduces galaxy rotation curve flattening and wide-binary velocity anomalies with predictive accuracy comparable to MOND, but lacks a covariant energy-momentum conserving field theory.
Empirical comparison of rotation curve fits in MNRAS (McCulloch 2007) contrasted with theoretical field-theoretic critiques.
- Modelling the Pioneer anomaly as modified inertia (Monthly Notices of the Royal Astronomical Society, 2007, computational)
- T3 · Observational, largeDark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales →
Across disc and dwarf galaxies, the departure from Newtonian/GR rotation velocities occurs exclusively when centripetal acceleration drops below a_0 ~ 1.2 x 10^-10 m/s^2, requiring Lambda-CDM to tune 2–3 halo parameters per galaxy to match what visible baryons predict directly.
Established by Rubin & Ford (1970) and systematically verified across 153 SPARC galaxies in Physical Review Letters (McGaugh, Lelli & Schombert 2016).
- Radial Acceleration Relation in Rotationally Supported Galaxies (Physical Review Letters, 2016, cohort)
- Rotation of the Andromeda Nebula from a Spectroscopic Survey of Emission Regions (The Astrophysical Journal, 1970, cohort)
- T3 · Observational, largeModified Newtonian Dynamics (MOND), Relativistic Extensions & Galactic Dynamics →
In the merging galaxy cluster 1E 0657-56 (the Bullet Cluster), the 8-sigma spatial separation between weak lensing centroids and X-ray baryonic plasma cannot be explained by standard non-relativistic MOND without introducing additional unseen mass.
Empirical weak lensing and X-ray observations in The Astrophysical Journal Letters (Clowe et al. 2006).
- A direct empirical proof of the existence of dark matter (The Astrophysical Journal Letters, 2006, cohort)
- T3 · Observational, largeDebatedDark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales →
Small-scale Lambda-CDM cosmological tensions—including the cusp-core discrepancy in dwarf galaxies and phase-space planar alignments of satellite galaxies—consistently align with modified gravity predictions without fine-tuned baryonic feedback subgrid recipes.
Observational surveys of dwarf spheroidals and satellite planes in the Local Group contrasted with cosmological simulations.
- Radial Acceleration Relation in Rotationally Supported Galaxies (Physical Review Letters, 2016, cohort)
- T3 · Observational, largeDebatedModified Newtonian Dynamics (MOND), Relativistic Extensions & Galactic Dynamics →
The External Field Effect (EFE), a unique prediction of MOND violating the Strong Equivalence Principle, has been detected in rotation curves and dwarf galaxy velocity dispersions (e.g. Crater II) immersed in external gravitational fields.
Observational cohort study in The Astrophysical Journal (Chae et al. 2020) reporting 4-sigma detection of EFE in SPARC galaxies.
- Testing the Strong Equivalence Principle: Detection of the External Field Effect in Rotationally Supported Galaxies (The Astrophysical Journal, 2020, cohort)
Ultra-precise astrometric velocities of wide binary star systems with separations s > 2,000 AU in Gaia DR3 deviate from Newtonian gravity, manifesting an acceleration-dependent velocity boost matching Milgromian dynamics.
Chae 2023 statistical analysis of 26,615 clean wide binary systems at a ≲ 10^-10 m/s^2, contested by triple-star companion hypotheses.
- Breakdown of the Newton-Einstein Standard Gravity at Low Acceleration in Internal Dynamics of Wide Binary Stars (The Astrophysical Journal, 2023, cohort)
- T5 · Preclinical or mechanisticModified Newtonian Dynamics (MOND), Relativistic Extensions & Galactic Dynamics →
Milgrom's original 1983 MOND formulation predicted that galactic rotation curves would remain flat at large radii with an asymptotic velocity v_f^4 = G * M * a_0 decades before dwarf galaxy data verified the relationship.
Original mathematical derivation in The Astrophysical Journal (Milgrom 1983).
- A modification of the Newtonian dynamics as a possible alternative to the hidden mass hypothesis (The Astrophysical Journal, 1983, computational)
- T5 · Preclinical or mechanisticQuantum Mechanics: Wave Mechanics, Entanglement, Nonlocality & Measurement →
Macromolecular matter-wave interference demonstrates that quantum superpositions persist across systems exceeding 25,000 atomic mass units (2,000 atoms).
Talbot-Lau matter-wave interferometry by Fein et al. (2019) at the University of Vienna.
- Quantum superposition of molecules beyond 25 kDa (Nature Physics, 2019, in vitro)
Jacob Bekenstein's TeVeS was the first covariant relativistic theory reproducing MOND in the weak-field limit, though it requires vector field fine-tuning and struggles to fit CMB acoustic peaks.
Theoretical analysis in Physical Review D (Bekenstein 2004) proving covariant lensing and weak-field MOND, later superseded by AeST for cosmology.
- Relativistic gravitation theory for the modified Newtonian dynamics paradigm (Physical Review D, 2004, computational)
- T5 · Preclinical or mechanisticCondensed Matter, Atomic, Molecular & Optical Physics →
Graphene is a rapidly rising star on the horizon of materials science and condensed-matter physics.
Extracted from indexed computational literature (2007, 9822 citations).
- The rise of graphene. (Nature materials, 2007, computational)
- T5 · Preclinical or mechanisticCondensed Matter, Atomic, Molecular & Optical Physics →
There are few phenomena in condensed matter physics that are defined only by the fundamental constants and do not depend on material parameters.
Extracted from indexed computational literature (2008, 2333 citations).
- Fine structure constant defines visual transparency of graphene. (Science (New York, N.Y.), 2008, computational)
- T6 · Opinion, news or unverifiedCondensed Matter, Atomic, Molecular & Optical Physics →
Research on graphene and other two-dimensional atomic crystals is intense and is likely to remain one of the leading topics in condensed matter physics and materials science for many years.
Extracted from indexed expert opinion literature (2013, 3510 citations).
- Van der Waals heterostructures. (Nature, 2013, expert opinion)
- T6 · Opinion, news or unverifiedCondensed Matter, Atomic, Molecular & Optical Physics →
Phase transitions are ubiquitous in nonliving matter, and recent discoveries have shown that they also play a key role within living cells.
Extracted from indexed expert opinion literature (2017, 3478 citations).
- Liquid phase condensation in cell physiology and disease. (Science (New York, N.Y.), 2017, expert opinion)
- T1 · Synthesis of trialsOocyte Nuclear Maturity (MII/MI/GV) & Morphological Grading →
Systematic review of 50 clinical studies shows that isolated minor extracytoplasmic oocyte dysmorphisms (polar body fragmentation, dark zona, small perivitelline debris) do not reliably reduce fertilisation or live-birth potential, whereas visible Metaphase II spindle birefringence positively predicts embryo developmental competence.
Rienzi et al. systematic review in Human Reproduction Update (2011).
- The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting (Human Reproduction, 2011, guideline)
- Predictive value of oocyte morphology in human IVF: a systematic review of the literature (Human Reproduction Update, 2011, systematic review)
Papers, preprints & clinical trials (24)
- Strong constraints on modified Newtonian dynamics showing failure at low accelerations in Gaia DR3 wide binaries — Indranil Banik, Hosein Haghi, Pavel Kroupa · Monthly Notices of the Royal Astronomical Society · 2024 · cohort · 55 citations
DOI: 10.1093/mnras/stad3393 · Read abstract & full text at official source ↗
- Gaia DR3 wide binaries as a test of gravity: confirmation of a non-Newtonian acceleration in the low-acceleration regime — X. Hernandez, R. L. Cortés, R. A. M. Scarpa · Monthly Notices of the Royal Astronomical Society · 2023 · cohort · 65 citations
DOI: 10.1093/mnras/stad2626 · Read abstract & full text at official source ↗
- First Dark Matter Search Results from the LUX-ZEPLIN (LZ) Experiment — J. Aalbers et al. (LUX-ZEPLIN Collaboration) · Physical Review Letters · 2023 · in vitro · 490 citations
DOI: 10.1103/physrevlett.131.041002 · Read abstract & full text at official source ↗
- Advances in biodiversity: metagenomics and the unveiling of biological dark matter. — Robbins RJ, Krishtalka L, Wooley JC · Standards in genomic sciences · 2016 · computational · 14 citations
DOI: 10.1186/s40793-016-0180-8 · Read abstract & full text at official source ↗
Indexed in: Biology & Life Sciences - A direct empirical proof of the existence of dark matter — Douglas Clowe, Maruša Bradač, Anthony H. Gonzalez · The Astrophysical Journal Letters · 2006 · cohort · 3400 citations
DOI: 10.1086/508162 · Read abstract & full text at official source ↗
- Dark matter: theoretical perspectives. — Turner MS · Proceedings of the National Academy of Sciences of the United States of America · 1993 · expert opinion · 1 citations
DOI: 10.1073/pnas.90.11.4827 · Read abstract & full text at official source ↗
Indexed in: Physics & Cosmology - The Fisher-Tully Law solely with 1915 General Relativity and Dark Energy — Cornwall R · Preprints.org · 2024 · expert opinion
DOI: 10.20944/preprints202404.0669.v3 · Read abstract & full text at official source ↗
Indexed in: Modified, Emergent & Frontier Gravity Theories - Breakdown of the Newton-Einstein Standard Gravity at Low Acceleration in Internal Dynamics of Wide Binary Stars — Kyu-Hyun Chae · The Astrophysical Journal · 2023 · cohort · 110 citations
DOI: 10.3847/1538-4357/ace773 · Read abstract & full text at official source ↗
Indexed in: Physics & Cosmology - Breakdown of the Newton-Einstein Standard Gravity at Low Acceleration in Internal Dynamics of Wide Binary Stars — Kyu-Hyun Chae · The Astrophysical Journal · 2023 · cohort · 85 citations
DOI: 10.3847/1538-4357/ace79e · Read abstract & full text at official source ↗
- Fine particulate matter exposure and sperm DNA fragmentation in US men: a spatial cross-sectional study. — Fouks Y, Vaughan DA, Bortoletto P · Human reproduction (Oxford, England) · 2025 · expert opinion · 4 citations
DOI: 10.1093/humrep/deaf173 · Read abstract & full text at official source ↗
- Breaking the 7 Mb barrier: Clinical cohort validation of genome-wide NIPT with fetal fraction enrichment and BinDel for detection of 1 Mb microdeletions and - duplications — Karmen Vaiküll, Priit Paluoja, Signe Mölder · medRxiv · 2026 · cohort
DOI: 10.64898/2026.02.10.26345955 · Read abstract & full text at official source ↗
- Equation of State Parameters for Stringy Particles in Cosmology with Dark Energy — Hong S, Lee B · Preprints.org · 2026 · expert opinion
DOI: 10.20944/preprints202601.1300.v1 · Read abstract & full text at official source ↗
- Clinical features and outcomes of peripartum obstetric patients admitted to the intensive care unit: A nationwide inpatient database in Japan. — Naruse S, Nakajima M, Aoki Y · Critical care (London, England) · 2025 · cohort
DOI: 10.1186/s13054-025-05597-z · Read abstract & full text at official source ↗
- Joint profiling of 5mC, 5hmC, and the transcriptome in single cells identifies factors responsible for genome-wide DNA methylation erasure in human primordial germ cell maturation — Chialastri A, Heom KA, Gell JJ · bioRxiv · 2025 · computational
DOI: 10.1101/2025.04.01.646736 · Read abstract & full text at official source ↗
Indexed in: Germ Cell Epigenetic Reprogramming - Maternal and perinatal outcomes in women aged 50 years and older: A nationwide cross-sectional study. — Sugai S, Tanaka T, Yamamoto H · The journal of obstetrics and gynaecology research · 2025 · guideline
DOI: 10.1111/jog.70063 · Read abstract & full text at official source ↗
Indexed in: Advanced Maternal Age & Pregnancy After 40 - The Zoomification Effect: How Virtual Selling is Costing Enterprise Deals 23% in Value—And the Neuroscience Behind Why Handshakes Still Matter — Simon Suwanzy Dzreke, Semefa Elikplim Dzreke, Evans Dzreke · International Journal For Multidisciplinary Research · 2025 · unknown
DOI: 10.36948/ijfmr.2025.v07i03.48943 · Read abstract & full text at official source ↗
Indexed in: Pharmacological Adjuvants - P-754 Association between ovarian hyperstimulation syndrome and adverse obstetric and neonatal outcomes in Korea: a nationwide health insurance database study — Jae-Hwan Kim, Y Park, Jae Young Park · Human Reproduction · 2024 · registry
DOI: 10.1093/humrep/deae108.042 · Read abstract & full text at official source ↗
- Maternal Copy Number Imbalances in Non-Invasive Prenatal Testing: Do They Matter? — Michaela Hýblová, Andrej Gnip, Marcel Kucharík · Diagnostics · 2022 · 9 citations
DOI: 10.3390/diagnostics12123056 · Read abstract & full text at official source ↗
- Sensitive protein alignments at tree-of-life scale using DIAMOND. — Buchfink B, Reuter K, Drost HG · Nature methods · 2021 · expert opinion · 4448 citations
DOI: 10.1038/s41592-021-01101-x · Read abstract & full text at official source ↗
- Maternal occupational exposure to endocrine-disrupting chemicals during pregnancy and semen parameters in adulthood: results of a nationwide cross-sectional study among Swiss conscripts — Marion Istvan, Rita Rahban, Brigitte Dananché · Human Reproduction · 2021 · cross sectional · 29 citations
DOI: 10.1093/humrep/deab034 · Read abstract & full text at official source ↗
- Worldwide decline of the entomofauna: A review of its drivers — Sánchez-Bayo F, Wyckhuys KAG · Biological Conservation. · 2019 · expert opinion · 644 citations
DOI: 10.1016/j.biocon.2019.01.020 · Read abstract & full text at official source ↗
- Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association — Smith, Sidney C., Jr. · Deep Blue (University of Michigan) · 2019 · expert opinion · 379 citations
DOI: 10.17615/fwet-2z17 · Read abstract & full text at official source ↗
- Worldwide decline of IVF birth rates and its probable causes — Norbert Gleicher, Vitaly A. Kushnir, David H. Barad · Human Reproduction Open · 2019 · registry · 132 citations
DOI: 10.1093/hropen/hoz017 · Read abstract & full text at official source ↗
Indexed in: In Vitro Fertilization and Embryo Culture - Genome-wide haplotyping embryos developing from 0PN and 1PN zygotes increases transferrable embryos in PGT-M — Aspasia Destouni, Eftychia Dimitriadou, Heleen Masset · Human Reproduction · 2018 · cohort · 69 citations
DOI: 10.1093/humrep/dey325 · Read abstract & full text at official source ↗
Indexed in: Zygote and Pronuclear Morphology Scoring
Disciplines & indexed entities
- Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales6 findings
Epistemic audit of per-galaxy ΛCDM halo parameter fitting and 40-year WIMP direct-detection nulls versus the empirical breakdown of General Relativity in galactic rotation curves and Gaia DR3 wide binary star systems.
Milgrom's acceleration threshold a0 ≈ 1.2×10^-10 m/s^2, zero-parameter Baryonic Tully–Fisher and Radial Acceleration Relations across SPARC galaxies, the External Field Effect, and AeST relativistic field theory.
Electronic band structure, superconductivity, topological phases of matter, Bose–Einstein condensates, quantum optics, and photonics.
Mike McCulloch's Hubble-scale Casimir/Rindler horizon model of inertia, Unruh radiation damping, zero-parameter galaxy rotation and wide-binary predictions, and laboratory horizon-drive/anti-gravity thrust bounds.
Synthesise the peer-reviewed record on Embryo glue: systematic reviews, randomised clinical trials, large cohort studies, quantitative effect sizes, safety signals, and active trials.
Local SU(3)_C × SU(2)_L × U(1)_Y Yang–Mills gauge theory, QED anomalous magnetic moment precision, QCD asymptotic freedom and confinement, the Brout–Englert–Higgs mechanism, neutrino oscillations, and g-2 tensions.
Relativistic strings, Green–Schwarz anomaly cancellation, 11D M-theory, D-brane black hole microstates, Maldacena's AdS/CFT duality, the 10^500 landscape, and Swampland constraints.
Performance of non-invasive prenatal testing (cfDNA), invasive diagnostic testing, and detection rates of maternal and fetal chromosomal abnormalities in late maternal age pregnancies.
Synthesise the peer-reviewed record on frontier studies on 40+ fertility and new clinical trials: systematic reviews, randomised clinical trials, large cohort studies, quantitative effect sizes, safety signals, and active trials.
Chromosomal aneuploidy screening, single-gene disease diagnosis, and polygenic trait risk scoring in early embryo selection.
- Ectogenesis and Ex Utero Embryology22 findings
Artificial placenta development, extended ex vivo embryo culture beyond traditional developmental windows, and uterine bioengineering.
- Assisted reproduction19 findings
Research IVF and new potential venues such as out of womb embryology and egg donor DNA replacement, etc... what else is there in the edge?
- Autologous Ovarian Rejuvenation Therapies19 findings
Investigates intraovarian injections of autologous platelet-rich plasma (PRP), bone marrow-derived stem cells, and cell-free secretomes or exosomes to restore folliculogenesis in diminished ovarian reserve.
- Embryo Morphokinetics and Time-Lapse Imaging18 findings
Dynamic tracking of cleavage timing, cell cycle intervals (t2, t3, t5, t8, tSB, tB), and abnormal division events (direct cleavage, reverse cleavage).
- Polyps Resurgence in Uterine Tissue - How Frequent and How Much Time They Usually Re-appear18 findings
Synthesise the peer-reviewed record on Polyps resurgence in uterine tissue - how frequent and how much time they usually re-appear? And how do they diminish fertility if at all: systematic reviews, randomised clinical trials, large cohort studies, quantitative effect sizes, safety signals, and active trials.
Risk factors associated with accelerated polyp resurgence, including parity, body mass index, tamoxifen therapy, polycystic ovary syndrome, and lesion multiplicity.
Focuses on in vitro follicle activation (IVA), signaling pathway modulation (Akt/PTEN/mTOR pathway), and tissue-engineered bioartificial ovaries for germline preservation and activation.
- Endometrial Polyp Recurrence Kinetics17 findings
Epidemiology, incidence rates, and time-to-recurrence distributions following hysteroscopic resection across different patient demographics.
Synthesise the peer-reviewed record on supplements: systematic reviews, randomised clinical trials, large cohort studies, quantitative effect sizes, safety signals, and active trials.
- Germ Cell Epigenetic Reprogramming14 findings
Examination of the molecular mechanisms, including DNA methylation and histone modification, that regulate the rejuvenation or restoration of competency in aged gametes.
Analysis of systemic hormonal therapies, including androgen and gonadotropin support, to improve gamete quality in clinical settings.
- Micronutrients14 findings
Systematic review of Vitamin D, Folate, and trace minerals (Zinc, Selenium) and their correlation with live birth rates in older cohorts.
- Comparative Formulations & Health Economics13 findings
Variation in commercial hyaluronan concentrations, comparison with standard culture media, cost-effectiveness analyses, and regulatory evidence ratings across international bodies.
- Reproductive Medicine & Human Fertility12 findings
Physiology, epidemiology, pathology, and clinical interventions in human reproduction across the lifespan, including gametogenesis, ovarian reserve, cryopreservation, endometrial receptivity, andrology, assisted reproductive technology, maternal-fetal medicine, and translational reproductive biology.
- Mordehai Milgrom · Israel (person)
Theoretical physicist at the Weizmann Institute of Science who formulated Modified Newtonian Dynamics (MOND) in 1983 to explain flat galaxy rotation curves without dark matter.
Branch: Physics & Cosmology
- Erik Verlinde · Netherlands (person)
Theoretical physicist and string theorist at the University of Amsterdam, known for proposing the entropic/emergent gravity hypothesis.
- Indranil Banik · United Kingdom (person)
Postdoctoral Research Fellow at the University of St Andrews specializing in testing gravitational theories across galaxies and wide binary systems.
Branch: Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales
- Kyu-Hyun Chae · South Korea (person)
Professor of Astronomy at Sejong University, known for detecting the External Field Effect in SPARC galaxies and studying low-acceleration gravity in Gaia wide binaries.
Branch: Modified Newtonian Dynamics (MOND), Relativistic Extensions & Galactic Dynamics
- Kyu-Hyun Chae · South Korea (person)
Professor of Astronomy at Sejong University who identified the gravitational boost in Gaia DR3 wide binary systems at a < 10^-10 m/s^2.
Branch: Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales
- LUX-ZEPLIN (LZ) Collaboration · United States (lab)
International direct dark matter detection experiment operating a 7-tonne active liquid xenon detector 4,850 feet underground at SURF in Lead, South Dakota.
Branch: Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales
- Laboratori Nazionali del Gran Sasso (INFN LNGS) · Italy (lab)
World's largest deep underground research facility shielded under 1400 meters of rock, conducting ultra-low-background tests of gravitational wavefunction collapse.
Branch: Sir Roger Penrose: Mathematical Physics, Twistor Theory & Cosmology
- Alan Mathison Turing · United Kingdom (person)
Mathematician, logician, and cryptanalyst widely considered the father of theoretical computer science and artificial intelligence.
- Constantinos Skordis · Czech Republic (person)
Cosmologist and theoretical physicist at the Institute of Physics of the Czech Academy of Sciences, co-creator of the AeST relativistic MOND theory.
- Eugene F. Fama · United States (person)
Nobel laureate widely known as the father of modern finance, creator of the Efficient Market Hypothesis and empirical factor pricing models.
Branch: Financial Markets, Asset Pricing & Market Microstructure
- IQOQI Vienna (Institute for Quantum Optics and Quantum Information) · Austria (lab)
Austrian Academy of Sciences research center led by Anton Zeilinger and Markus Arndt pioneering multi-particle entanglement and macromolecular interferometry.
Branch: Quantum Mechanics: Wave Mechanics, Entanglement, Nonlocality & Measurement
- Max Planck Institute of Quantum Optics (MPQ) · Germany (lab)
European center of excellence in quantum optics, laser spectroscopy, and ultracold quantum simulators led by Immanuel Bloch and Theodor Hänsch.
Branch: Condensed Matter, Atomic, Molecular & Optical Physics
- Mordehai Milgrom · Israel (person)
Originator of Modified Newtonian Dynamics (MOND) and Professor Emeritus at the Weizmann Institute of Science.
Branch: Modified Newtonian Dynamics (MOND), Relativistic Extensions & Galactic Dynamics
- Mordehai Milgrom · Israel (person)
Theoretical physicist at the Weizmann Institute of Science who proposed Modified Newtonian Dynamics (MOND) in 1983.
- QuTech (Delft University of Technology & TNO) · Netherlands (lab)
Quantum technology research institute that performed the first loophole-free Bell inequality violation using diamond NV centers in 2015.
Branch: Quantum Mechanics: Wave Mechanics, Entanglement, Nonlocality & Measurement
- Xavier Hernandez · Mexico (person)
Professor at the Institute of Astronomy, UNAM, pioneer in wide binary star gravitational tests and modified gravity phenomenology.
Branch: Dark Matter Ad-Hoc Parameters vs. General Relativity Breakdown at Galactic & Wide-Binary Scales