Alexander’s Library

The search for the elixir of youth — what the record says, and how strongly. Double-click any word for an instant dictionary or scientific synopsis.

Library / Natural & Life Sciences / Medicine, Health & Longevity / Reproductive Medicine & Human Fertility / Lifestyle, Metabolic Health & Natural Conception Optimization

Micronutrient, Antioxidant & Mitochondrial Fertility Supplementation

Synthesise the peer-reviewed record on supplements: systematic reviews, randomised clinical trials, large cohort studies, quantitative effect sizes, safety signals, and active trials.

94 sources ↓Last researched 2026-10-20
Hierarchy:
Natural & Life SciencesMedicine, Health & LongevityReproductive Medicine & Human FertilityLifestyle, Metabolic Health & Natural Conception OptimizationMicronutrient, Antioxidant & Mitochondrial Fertility SupplementationLeaf node (no child sub-branches yet)
+ Associated nodes:
Blastocyst Morphological Grading (Gardner AA/BB) & Zygote Pronuclear Scoring (2PN/1PN) (intersects) Lifestyle, Metabolic Health & Natural Conception Optimization (intersects) Reproductive Nutrition, Dietary Patterns & Ovulatory Function (intersects) Polyps Resurgence in Uterine Tissue - How Frequent and How Much Time They Usually Re-appear (intersects) Male & Ovarian Gamete Rejuvenation, Spermatogenesis & Follicular Activation (intersects) Reproductive Medicine & Human Fertility (intersects)
State of the Field Monograph · AI Research Synthesis3 min read · 94 sources · 15 graded findingsPeak certainty: T1

State of the Field: Reproductive Supplements in Advanced Maternal Age and Ovarian Aging

An evidence-based audit of mitochondrial cofactors, androgen adjuncts, and metabolic inositols in human fertility after 40

Synopsis · Executive Overview

As reproductive aging introduces mitochondrial dysfunction and oxidative stress into oocytes, clinical practice increasingly incorporates targeted supplementation. While Coenzyme Q10 enjoys robust meta-analytic support for improving pregnancy metrics and oocyte yield, other adjuncts like DHEA and testosterone remain sharply debated due to conflicting trial outcomes and modest sample sizes. This monograph synthesizes current literature, separating commercial marketing from verified clinical endpoints.

Section I · Mitochondrial & Metabolic Support

Coenzyme Q10 and Inositols: Mechanisms and Clinical Outcomes

Mitochondrial deterioration is a hallmark of oocyte aging, characterized by declining ATP production and increased reactive oxygen species. Coenzyme Q10 (CoQ10) targets specific hub proteins and restores mitochondrial electron transport chain efficiency. Meta-analytic data encompassing 1,529 participants demonstrate that CoQ10 pretreatment significantly enhances clinical pregnancy rates and oocyte yield while depressing cycle cancellation and miscarriage rates.

Similarly, inositol isomers—specifically myo-inositol and D-chiro-inositol—act as second messengers for insulin signaling. In populations with insulin resistance or PCOS, inositol administration improves oocyte quality, lowers androgen excess, and elevates fertilization rates from 71.61% to 77.66% in retrospective cohorts. These interventions represent the most biochemically grounded category of reproductive supplements.

Section II · Androgen Priming Contests

DHEA and Testosterone in Diminished Ovarian Reserve

The use of androgen precursors such as dehydroepiandrosterone (DHEA) and testosterone to rescue poor ovarian response remains one of the most contentious areas in reproductive medicine. Early meta-analyses of DHEA adjuvant therapy reported encouraging clinical pregnancy rate increases (RR 2.13; 95% CI 1.12-4.08) among women with diminished ovarian reserve. However, concurrent systematic reviews evaluating restricted or smaller trial cycles argue that data remains insufficient to confirm definitive live birth improvements.

Testosterone supplementation similarly shows elevated oocyte counts and promising live birth trends across limited randomized cohorts (n=368). Critics emphasize that while biochemical markers like AMH or AFC may shift transiently, robust, multi-center randomized controlled trials proving sustained live-birth superiority over standard IVF protocols are urgently needed.

Evidence Hierarchy (Graded Claims)

  • T1Synthesis of trials
    8 (53%)
  • T2Randomised trial
    0 (0%)
  • T3Observational, large
    2 (13%)
  • T4Observational, small or case-based
    3 (20%)
  • T5Preclinical or mechanistic
    2 (13%)
  • T6Opinion, news or unverified
    0 (0%)
7 settled8 debated0 contested / frontier

Study Designs in Indexed Literature

  • Meta-analyses, Systematic Reviews & Guidelines37 (39%)
  • Randomised Controlled Trials (RCTs)12 (13%)
  • Prospective Cohorts & Clinical Registries6 (6%)
  • Preclinical, Cellular & Computational Models6 (6%)
  • Primary Literature & Archive Records33 (35%)

Publication Timeline Velocity

Fig. 1 — Field Evidence Architecture & Publication Trajectory. Distribution of methodological study designs (94 indexed publications) and 15 extracted claims graded from T1 (meta-analyses and guidelines) to T6.

Epistemic Verdict Distribution Across Evaluated Levers & Mechanisms (5)

Supported1 lever (20%)
Case by case1 lever (20%)
Targeted2 levers (40%)
Trial only1 lever (20%)
Fig. 2 — Intervention & Mechanism Epistemic Calibration. Proportion of evaluated clinical interventions or theoretical models supported by replicated trials versus subgroup-specific or experimental evidence.
Primary Citations & Landmark Studies

Key Studies Anchoring This Monograph

Synthesis & Conclusions

State of the Field Conclusions

The clinical management of reproductive aging with supplements requires rigorous differentiation between well-supported metabolic/mitochondrial adjuncts and debated endocrine stimulators. CoQ10 and targeted inositols offer reliable, evidence-backed improvements in oocyte yield and metabolic markers. Conversely, androgen therapies like DHEA must be approached with measured clinical caution, reserving their use for specific, refractory patient subsets pending definitive large-scale randomized trials.

Key Quantitative Takeaways

  • Coenzyme Q10 pretreatment is supported by meta-analytic data of 1,529 participants, demonstrating improved clinical pregnancy rates and reduced miscarriage.
  • Myo-inositol improves metabolic profiles, insulin sensitivity, and fertilization metrics (77.66% vs 71.61%) in targeted subgroups.
  • DHEA and testosterone remain debated, with older positive meta-analyses (RR 2.13) countered by reviews citing insufficient data for live births.
  • Antioxidants such as melatonin and vitamins mitigate intrafollicular oxidative stress, though dosage standardization remains incomplete.
1,529

Total participants evaluated in CoQ10 meta-analyses for diminished ovarian reserve

Meta-analysis of CoQ10 in IVF/ICSI

RR 2.13

Clinical pregnancy rate improvement with DHEA in diminished ovarian reserve (95% CI 1.12-4.08)

Meta-analysis of 8 studies (2015)

77.66% vs 71.61%

Fertilization rate in PCOS cohorts pre-treated with inositol and antioxidants

Retrospective cohort study (2026)

Where each lever applies

A graded decision ledger of interventions across clinical subgroups. Each row names its best landmark evidence, measured effect, clinical reading, and epistemic verdict.

Supported: RCT live-birth gainTargeted: specific subgroupGuideline: clinical consensusWeak: inconsistent/unproven gainNot supported: RCTs show no gainTrial: human trial in progressLab: preclinical / cell dish

Ovarian adjuncts

Lever & MechanismBest Landmark EvidenceMeasured Effect & Clinical ReadingVerdict
Coenzyme Q10

Mitochondrial electron transport chain cofactor and antioxidant targeting ATP production and oxidative stress reduction in oocytes.

Meta-analysis of 1529 participants and Poseidon Group 3 RCT (n=169)

Effect: Improves clinical pregnancy rates, reduces cycle cancellation and miscarriage rates, lowers gonadotropin requirements

Clinical reading: Supported for mitochondrial support in diminished ovarian reserve and advanced maternal age.

Supported
Dehydroepiandrosterone (DHEA)

Androgen precursor administered to enhance follicular microenvironments and androgen receptor expression in poor responders.

Meta-analysis of 8 studies and subsequent conflicting systematic reviews

Effect: Clinical pregnancy RR 2.13 (95% CI 1.12-4.08) in positive models; countered by reviews citing insufficient data

Clinical reading: Contested and debated due to high heterogeneity and conflicting trial results regarding live births.

Case by case
Testosterone Supplementation

Direct androgen priming to rescue follicular response in diminished ovarian reserve.

Randomized trials analyzing n=368 patients across 4 studies

Effect: Higher live birth rates and increased total oocyte counts in reported subsets

Clinical reading: Requires careful patient selection; trial only status due to limited large-scale replication.

Trial only

Metabolic & Cellular

Lever & MechanismBest Landmark EvidenceMeasured Effect & Clinical ReadingVerdict
Myo-Inositol & D-Chiro-Inositol

Secondary messenger system regulators (commonly 40:1 ratio) improving insulin sensitivity and oocyte quality.

Systematic reviews of RCTs and retrospective cohorts (n=1319 and n=92)

Effect: Enhances fertilization rates (77.66% vs 71.61%) and reduces gestational diabetes risk

Clinical reading: Guideline or strongly targeted for PCOS populations; beneficial for metabolic regulation.

Targeted

Cellular & Nuclear

Lever & MechanismBest Landmark EvidenceMeasured Effect & Clinical ReadingVerdict
Melatonin

Intrafollicular antioxidant scavenging free radicals and improving maturation rates.

Clinical trials and systematic reviews across doses of 2 to 18 mg/day

Effect: Reduces intrafollicular oxidative damage and increases embryo count

Clinical reading: Useful targeted adjunct for unexplained infertility and oxidative stress profiles.

Targeted

Questions for specialist consultations

High-yield clinical and laboratory inquiries directly derived from the evidence record.

  1. What is the targeted biological rationale (e.g., mitochondrial restoration vs. androgen priming) for prescribing CoQ10 versus DHEA in my specific clinical subgroup?
  2. What exact plasma or follicular biomarker levels are we attempting to optimize with this supplement regimen, and how long is the mandatory pre-treatment window?
  3. Are there potential hepatic, metabolic, or hormonal adverse interaction risks when combining high-dose antioxidants with androgen precursors?
  4. What concrete live birth rate improvements have been demonstrated in randomized trials for patients matching my exact age and ovarian reserve profile?

Queued for next research sweep

Frontier clinical trials, emerging biology, and targeted subgroup outcomes tracked by the autonomous research worker.

  • Large-scale randomized controlled trials isolating the independent live-birth impact of DHEA versus placebo in women aged 40+ with normal vs diminished ovarian reserve.
  • Network pharmacology and multi-omic profiling of combined CoQ10 and melatonin protocols on human oocyte spindle integrity.
  • Standardization trials establishing optimal inositol isomer ratios (40:1 vs 3.6:1) for non-PCOS advanced maternal age populations.
  • Safety and efficacy tracking of short-term testosterone priming regimens on endometrial receptivity markers.
Evidence by study design (15 findings across T1–T6)

Strongest support first. The bar beside each finding shows its grade.

Synthesis of trials

  1. #1 Narrative and systematic reviews report that myo-inositol (MYO) alone or combined with D-chiro-inositol (DCI) at a 40:1 ratio improves insulin sensitivity, lowers androgen levels, and enhances oocyte quality in polycystic ovary syndrome.

    Effect of myo-inositol and d-chiro-inositol on improving hormonal, m… (2025); Update on the combination of myo-inositol/d-chiro-inositol for the t… (2024)

    Establishes inositol supplementation as a cornerstone metabolic and reproductive therapy for PCOS-related subfertility.

  2. #2 In a meta-analysis of 8 studies, dehydroepiandrosterone (DHEA) supplementation among women with diminished ovarian reserve undergoing IVF/ICSI increased the clinical pregnancy rate (RR 2.13; 95% CI 1.12-4.08).

    DebatedA meta‐analysis of dehydroepiandrosterone supplementation among wome… (2015); Efficacy of dehydroepiandrosterone to improve ovarian response in wo… (2013)

    Demonstrates the clinical benefit of DHEA supplementation on pregnancy rates in poor ovarian responders.

  3. #3 Coenzyme Q10 pretreatment significantly improves clinical pregnancy rates and oocyte yield while reducing cycle cancellation and miscarriage rates in women with diminished ovarian reserve undergoing IVF/ICSI, based on a meta-analysis of 1529 participants.

    Clinical evidence of coenzyme Q10 pretreatment for women with dimini… (2024)

    CoQ10 is widely studied as a mitochondrial supplement to restore egg quality in advanced age or diminished ovarian reserve.

  4. #4 Testosterone supplementation is associated with higher live birth rates and increased total oocyte counts in women with diminished ovarian reserve compared to non-supplemented controls across multiple randomized trials (n=368 patients analyzed for live birth across 4 studies).

    DebatedTherapeutic management in women with a diminished ovarian reserve: a… (2024)

    Systematic review evidence indicates androgen adjuvant treatment improves reproductive outcomes in DOR populations.

  5. #5 Antioxidants (such as vitamins C, E, CoQ10, zinc, selenium, and l-carnitine) counteract oxidative stress, protecting sperm function and improving reproductive outcomes in male infertility, although optimal dosages and combinations require further standardization.

    DebatedThe Role of Antioxidants in Male Fertility: A Comprehensive Review o… (2025); Oxidative Stress, Antioxidants, Gut Microbiota and Male Fertility (2025); Oxidative Stress and Male Infertility: The Protective Role of Antiox… (2023)

    Broad consensus supports antioxidant benefits for oxidative stress-driven male infertility, though protocol heterogeneity remains.

  6. #6 Melatonin supplementation reduces intrafollicular oxidative damage, improves oocyte maturation and fertilization rates, and enhances intrafollicular antioxidant balance in women with unexplained infertility.

    Impact of Melatonin Supplementation in Women with Unexplained Infert… (2019); The role of melatonin as an antioxidant in the follicle (2012)

    Highlights melatonin's dual role as a chronobiotic and potent direct free radical scavenger in follicular fluid.

  7. #7 Systematic reviews of melatonin indicate that daily doses of 2 to 18 mg for up to six months can improve oocyte quality, maturation, and embryo number via antioxidant mechanisms.

    DebatedThe usefulness of melatonin in the field of obstetrics and gynecology. (2019)

    Summarizes the clinical potential of short-term melatonin supplementation for reproductive performance.

  8. #8 Antenatal dietary supplementation with myo-inositol may reduce the incidence of gestational diabetes and hypertensive disorders of pregnancy, as shown in a systematic review of 7 randomised controlled trials involving 1319 women.

    DebatedAntenatal dietary supplementation with myo-inositol for preventing g… (2023)

    Myo-inositol improves insulin sensitivity and metabolic parameters during gestation, though the certainty of evidence is low to very low.

Observational, large

  1. #9 In young women with poor ovarian reserve (POSEIDON group 3), pretreatment with 60 days of coenzyme Q10 significantly lowers gonadotropin requirements, raises peak estradiol levels, and increases oocyte yield and high-quality embryo counts (n=169, RCT).

    Pretreatment with coenzyme Q10 improves ovarian response and embryo … (2018)

    Demonstrates that targeted CoQ10 supplementation improves clinical markers of ovarian stimulation response in younger poor-prognosis patients.

  2. #10 In a prospective cohort study of 103 women with diminished ovarian reserve, 8 weeks of DHEA supplementation (25 mg three times a day) increased serum testosterone, DHEAS, and androgen receptor mRNA expression in granulosa cells.

    DebatedThe effect of dehydroepiandrosterone supplementation on ovarian resp… (2017)

    Explains the potential molecular mechanism underlying DHEA responsiveness in poor ovarian reserve.

Observational, small or case-based

  1. #11 In a retrospective cohort study of 92 women with PCOS, pre-treatment with a 3.6:1 myo-inositol to D-chiro-inositol ratio and antioxidant-based supplement for at least 1 month prior to controlled ovarian stimulation improved fertilization rates (77.66% vs. 71.61%) and clinical pregnancy rates (54.39% vs. 42.65%).

    A 3.6:1 myo-inositol to D-chiro-inositol ratio and antioxidant-based… (2026)

    Highlights the synergistic benefit of specific inositol ratios combined with antioxidants in reproductive outcomes.

  2. #12 Combination therapy of myo-inositol with alpha-lactalbumin can re-establish ovulation in 86% of myo-inositol-resistant PCOS subjects, significantly increasing pregnancy prospects.

    DebatedEffects of myo-inositol plus alpha-lactalbumin in myo-inositol-resis… (2018)

    Overcoming metabolic resistance to standard inositol supplementation is an emerging frontier in fertility management.

  3. #13 In a quasi-experimental study of 36 women with diminished ovarian reserve, combination therapy with platelet-rich plasma and DHEA showed slightly greater improvements in AMH and AFC compared to DHEA alone, though differences were not statistically significant.

    DebatedEvaluating the effects of platelet-rich plasmas plus dehydroepiandro… (2025)

    Evaluates adjunctive regenerative therapies alongside standard hormone supplementation in poor responders.

Preclinical or mechanistic

  1. #14 Coenzyme Q10 restores oocyte mitochondrial function, increases ATP production, and mitigates age-related reproductive decline in animal and human models of reproductive aging.

    Coenzyme Q10 restores oocyte mitochondrial function and fertility du… (2015)

    Provides a mechanistic basis for using mitochondrial nutrients to target age-related oocyte deterioration.

  2. #15 Network pharmacology and molecular docking studies indicate that coenzyme Q10 (CoQ10) targets specific hub proteins (such as PPARA, CAT, MAPK14, SQSTM1, HMOX1, GRB2, and GSR) to exert antioxidant and anti-aging effects on oocytes.

    Systematic Understanding of Anti-Aging Effect of Coenzyme Q10 on Ooc… (2022)

    Provides a mechanistic basis for CoQ10 mitigation of age-related oocyte quality deterioration.

Where the record disagrees (2 controversies)

  • Contradiction between meta-analyses showing significant pregnancy rate improvements with DHEA and subsequent reviews declaring data insufficient for poor-responders.

    Findings #2

  • Testosterone and PRP/DHEA combinations rely on small sample sizes (n=368 and n=36) requiring larger multicenter trials.

    Findings #4, #13

Node lineage & crossover disciplines

Parent lineage, active node, direct child sub-branches, and associated crossover disciplines across the Tree of Knowledge.

Hierarchy:
Natural & Life SciencesMedicine, Health & LongevityReproductive Medicine & Human FertilityLifestyle, Metabolic Health & Natural Conception OptimizationMicronutrient, Antioxidant & Mitochondrial Fertility SupplementationLeaf node (no child sub-branches yet)
+ Associated nodes:
Blastocyst Morphological Grading (Gardner AA/BB) & Zygote Pronuclear Scoring (2PN/1PN) (intersects) Lifestyle, Metabolic Health & Natural Conception Optimization (intersects) Reproductive Nutrition, Dietary Patterns & Ovulatory Function (intersects) Polyps Resurgence in Uterine Tissue - How Frequent and How Much Time They Usually Re-appear (intersects) Male & Ovarian Gamete Rejuvenation, Spermatogenesis & Follicular Activation (intersects) Reproductive Medicine & Human Fertility (intersects)

Branches

No sub-branches yet. Autonomous research agents and the AI tree organiser spawn canonical sub-disciplines here when needed.

AI Tree OrganiserExpand Micronutrient, Antioxidant & Mitochondrial Fertility Supplementation

Branches are never named or placed manually. Ask any scientific question — AI decomposes multi-part inquiries into one, two, three, or more canonical sub-branches and places each under its proper discipline.

Public archive: please keep questions to general scientific concepts (no names, dates of birth, or personal health identifiers). Privacy & copyright.

Auto-classifies taxonomy & cross-links
Primary indexed sources (94)

Primary scientific literature, systematic reviews, and clinical trial registrations indexed for this branch.

  1. The Role of Anethole in Reproductive Physiology and In Vitro Biotechnologies—A Review — André Luiz da Conceição Santos, J.R. Figueiredo Reproduction in Domestic Animals, 2026, systematic review, 1 citations · DOI: 10.1111/rda.70176
  2. Placental nicotinamide adenine dinucleotide modulates the timing of labor — Erin J. Ciampa, Luana M. Machado, Kathy J. Lee et al. Science, 2026, animal, 1 citations · DOI: 10.1126/science.adz1624
  3. L26/P-146 Melatonin supplementation during in vitro maturation restores oocyte quality and developmental competence in aged mice — H. Park, K. Juhn, E. Jung et al. Human Reproduction, 2026, animal · DOI: 10.1093/humrep/deag083.482
  4. A 3.6:1 myo-inositol to D-chiro-inositol ratio and antioxidant-based food supplement before IVF improves fertility in women with PCOS: a pilot observational retrospective cohort study — Pedro Belchin, Virginia Calvente, Maria Jose Gómez Roso et al. Journal of Obstetrics and Gynaecology, 2026, cohort · DOI: 10.1080/01443615.2026.2681759
  5. Physiological Changes During Ischemia–Reperfusion Indicating Myocardial Damage Induced by Chronic and Excessive Consumption of Hibiscus sabdariffa L. — Linaloe Manzano-Pech, Marí­a Elena Soto, Juan Carlos Torres-Narváez et al. Toxics, 2026, animal · DOI: 10.3390/toxics14080671
  6. Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age Kaohsiung Veterans General Hospital., 2026, rct
  7. The Role of Antioxidants in Male Fertility: A Comprehensive Review of Mechanisms and Clinical Applications — David Bouhadana, Marie-Hélène Godin Pagé, Debbie Montjean et al. Antioxidants, 2025, systematic review, 38 citations · DOI: 10.3390/antiox14081013
  8. The role of androgens and global and tissue-specific androgen receptor expression on body composition, exercise adaptation, and performance — Sabrina Tzivia Barsky, D. Ashley Monks Biology of Sex Differences, 2025, systematic review, 18 citations · DOI: 10.1186/s13293-025-00707-6
  9. Oxidative Stress, Antioxidants, Gut Microbiota and Male Fertility — Natalia Kurhaluk Cellular Physiology and Biochemistry, 2025, expert opinion, 15 citations · DOI: 10.33594/000000802
  10. Nicotinamide mononucleotide supplementation improves oocyte developmental competence in different ovarian damage conditions. — Ramírez-Martín N, Buigues A, Rodríguez-Varela C et al. American journal of obstetrics and gynecology, 2025, animal, 10 citations · DOI: 10.1016/j.ajog.2025.02.006
  11. Oocyte and dietary supplements: a mini review — Hao Chen, Shuoqi Wang, Meiying Song et al. Frontiers in Cell and Developmental Biology, 2025, systematic review, 9 citations · DOI: 10.3389/fcell.2025.1619758
  12. Metformin and Myo-Inositol: A Comparative Analysis — Michele Russo, Mario Montanino Oliva, Maurizio Nordio et al. Gynecologic and Obstetric Investigation, 2025, unknown, 2 citations · DOI: 10.1159/000549646
  13. The Significant Role of Antioxidant Enzymes in The Pathogenesis and Potential Enhancement of Infertility — IGE ILESANMI PAUL, ILESANMI-IGE IRENE TITLOPE International Journal of Latest Technology in Engineering Management & Applied Science, 2025, systematic review · DOI: 10.51583/ijltemas.2025.140500060
  14. Effect of myo-inositol and d-chiro-inositol on improving hormonal, metabolic and reproductive parameters in women with polycystic ovary syndrome: A review of studies — Aleksandra Ciuła, Michał Borawski, Anna Jakubiak et al. Quality in Sport, 2025, systematic review · DOI: 10.12775/qs.2025.41.60350
  15. Evaluating the effects of platelet-rich plasmas plus dehydroepiandrosterone and dehydroepiandrosterone alone in infertile women with diminished ovarian reserve — Sohely Akter, Shaheen Ara Anwary, Amitun Nessa et al. International Journal of Reproduction Contraception Obstetrics and Gynecology, 2025, case control · DOI: 10.18203/2320-1770.ijrcog20251964
  16. Therapeutic management in women with a diminished ovarian reserve: a systematic review and meta-analysis of randomized controlled trials — Alessandro Conforti, Luigi Carbone, Raffaella Di Girolamo et al. Fertility and Sterility, 2024, systematic review, 51 citations · DOI: 10.1016/j.fertnstert.2024.09.038
  17. Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health — Celine Kapper, Peter Oppelt, Clara Ganhör et al. Nutrients, 2024, unknown, 31 citations · DOI: 10.3390/nu16071008
  18. Antioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects. — Saleh R, Sallam H, Elsuity MA et al. Frontiers in endocrinology, 2024, unknown, 28 citations · DOI: 10.3389/fendo.2024.1503905
  19. Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis — Guangyao Lin, Xuanling Li, Stella Lim Jin Yie et al. Annals of Medicine, 2024, systematic review, 21 citations · DOI: 10.1080/07853890.2024.2389469
  20. Update on the combination of myo-inositol/d-chiro-inositol for the treatment of polycystic ovary syndrome — Iñaki Lete, Ainara Martínez, Irene Lasaga et al. Gynecological Endocrinology, 2024, systematic review, 17 citations · DOI: 10.1080/09513590.2023.2301554
  21. Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary — Caifang Ren, Zhang Shuang, Yanyan Chen et al. The FASEB Journal, 2024, systematic review, 14 citations · DOI: 10.1096/fj.202400453r
  22. Vitamins, Coenzyme Q10, and Antioxidant Strategies to Improve Oocyte Quality in Women with Gynecological Cancers: A Comprehensive Review — Alexandru Isaic, Daciana Nistor, Alexandru Cătălin Motofelea et al. Antioxidants, 2024, unknown, 11 citations · DOI: 10.3390/antiox13121567
  23. The role of nicotinamide adenine dinucleotide salvage enzymes in cardioprotection — Fazle Kibria, SUDIP KUMAR DAS, Md Sahidul Arefin Polish Journal of Cardio-Thoracic Surgery, 2024, 1 citations · DOI: 10.5114/kitp.2024.141145
  24. Oxidative Stress and Male Infertility: The Protective Role of Antioxidants — Aris Kaltsas Medicina, 2023, systematic review, 192 citations · DOI: 10.3390/medicina59101769
  25. Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis. — Cimadomo D, Rienzi L, Conforti A et al. Human reproduction update, 2023, meta analysis, 145 citations · DOI: 10.1093/humupd/dmad010
  26. In vitro maturation (IVM) of human immature oocytes: is it still relevant? — Mausumi Das, Weon-Young Son Reproductive Biology and Endocrinology, 2023, systematic review, 65 citations · DOI: 10.1186/s12958-023-01162-x
  27. Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes — Soana Karuna Motuhifonua, Luling Lin, Jane Marie Alsweiler et al. Cochrane Database of Systematic Reviews, 2023, meta analysis, 35 citations · DOI: 10.1002/14651858.cd011507.pub3
  28. Sperm telomere length as a novel biomarker of male infertility and embryonic development: A systematic review and meta-analysis — Yacheng Yuan, Yangyang Tan, Xiaolong Qiu et al. Frontiers in Endocrinology, 2023, systematic review, 32 citations · DOI: 10.3389/fendo.2022.1079966
  29. Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood — Allison Bethanne Reiss, Shelly Gulkarov, Aaron Pinkhasov et al. Medicina, 2023, systematic review, 23 citations · DOI: 10.3390/medicina60010077
  30. Coenzyme Q10 Stimulate Reproductive Vatality — Xinyu Nie, Xinru Dong, Y. Hu et al. Drug Design Development and Therapy, 2023, unknown, 20 citations · DOI: 10.2147/dddt.s386974
  31. A Markov-model simulation of IVF programs for PCOS patients indicates that coupling myo-Inositol with rFSH is cost-effective for the Italian Health System — Ariel Béresniak, Michele Russo, Gianpiero Forte et al. Scientific Reports, 2023, 12 citations · DOI: 10.1038/s41598-023-44055-0
  32. Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve — Jing Wang, Xinyao Pan, Jing Zhou et al. Drug Discoveries & Therapeutics, 2023, 8 citations · DOI: 10.5582/ddt.2022.01109
  33. Nicotinamide Mononucleotide (NMN) as a Solution of Decrease Nicotinamide Adenine Dinucleotide (NAD+) in Aging — Ni Kadek Mei Permatasari, I Gusti Ngurah Agung Krisna Widiantara Bagus Putra, ‪Cokorda Agung Wahyu Purnamasidhi International Journal of Research and Review, 2023 · DOI: 10.52403/ijrr.20230871
  34. The Role of DHEA, NGF, and ADAMTS5 Pathways in Osteoarthritis and Current Developments — Duygu Sarı Ak, Nazlı Helvacı, Omar Alomarı et al. Bagcilar Medical Bulletin, 2023 · DOI: 10.4274/bmb.galenos.2023.2023-03-021
  35. Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements — Deanna M. Minich, Melanie Henning, Catherine Darley et al. Nutrients, 2022, expert opinion, 175 citations · DOI: 10.3390/nu14193934
  36. Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer — Lola E. Navas, Amancio Carnero Cells, 2022, systematic review, 65 citations · DOI: 10.3390/cells11172627
  37. Are Vitamin E Supplementation Beneficial for Female Gynaecology Health and Diseases? — Nur Amira Md Amin, Siti Hamimah Sheikh Abdul Kadir, Anam Arshad et al. Molecules, 2022, systematic review, 35 citations · DOI: 10.3390/molecules27061896
  38. Systematic Understanding of Anti-Aging Effect of Coenzyme Q10 on Oocyte Through a Network Pharmacology Approach — Liuqing Yang, Heng Wang, Sujie Song et al. Frontiers in Endocrinology, 2022, unknown, 27 citations · DOI: 10.3389/fendo.2022.813772
  39. Nicotinamide adenine dinucleotide metabolism: driving or counterbalancing inflammatory bowel disease? — Xinru Xue, Yumeng Miao, Zhifeng Wei FEBS Letters, 2022, 14 citations · DOI: 10.1002/1873-3468.14528
  40. Hair androgen concentrations and depressive disorders in adolescents from the general population — Hanna Kische, Catharina Voß, Robin Haring et al. European Child & Adolescent Psychiatry, 2022, 9 citations · DOI: 10.1007/s00787-021-01929-w
  41. Myo-inositol in polycystic ovary syndrome: a systematic review and positioning of its use — Durval Ribas Filho, Carlos Alberto Nogueira‐de‐Almeida, Idiberto José Zotarelli-Filho International Journal of Nutrology, 2022, systematic review, 1 citations · DOI: 10.54448/ijn22201
  42. Coenzyme Q10: Current Overview — Kadriye Erdoğan, Melahat Sedanur Macit, Nazlı Tunca Şanlıer et al. Türk Kadın Sağlığı ve Neonatoloji Dergisi, 2022, 1 citations · DOI: 10.46969/ezh.1002286
  43. Spontaneous Reproductive Outcomes After Oral Inositol Supplementation in Infertile Polycystic Ovarian Syndrome Women. Università degli Studi dell'Insubria, 2022, rct
  44. Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis — Andrea Busnelli, Edgardo Somigliana, Federico Cirillo et al. Scientific Reports, 2021, systematic review, 103 citations · DOI: 10.1038/s41598-021-81439-6
  45. Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality? — Cristina Rodríguez-Varela, Elena Labarta International Journal of Molecular Sciences, 2021, systematic review, 51 citations · DOI: 10.3390/ijms22179541
  46. Melatonin and Myo-Inositol: Supporting Reproduction from the Oocyte to Birth — Michele Russo, Gianpiero Forte, Mario Montanino Oliva et al. International Journal of Molecular Sciences, 2021, systematic review, 49 citations · DOI: 10.3390/ijms22168433
  47. Factors Influencing the In Vitro Maturation (IVM) of Human Oocyte — Huixia Yang, Thomas Kolben, Sarah Meister et al. Biomedicines, 2021, unknown, 39 citations · DOI: 10.3390/biomedicines9121904
  48. Editorial: Causes of Oocyte Aneuploidy and Infertility in Advanced Maternal Age and Emerging Therapeutic Approaches — Lori R. Bernstein, Nathan R. Treff Frontiers in Endocrinology, 2021, 15 citations · DOI: 10.3389/fendo.2021.652990
  49. Nicotinamide adenine dinucleotide and the sirtuins caution: Pro‐cancer functions — Raymond D. Palmer, Mauro Vaccarezza Aging Medicine, 2021, 14 citations · DOI: 10.1002/agm2.12184
  50. Inequality: The Dangers of Meat Haves and Have-Nots in a Nicotinamide-Adenine-Dinucleotide World — Adrian C. Williams, Lisa J. Hill IntechOpen eBooks, 2021, 3 citations · DOI: 10.5772/intechopen.96748
  51. Impact of Melatonin Supplementation in Women with Unexplained Infertility Undergoing Fertility Treatment — Javier Espino, María Macedo, Graciela M. Lozano et al. Antioxidants, 2019, rct, 100 citations · DOI: 10.3390/antiox8090338
  52. The Paradox of Coenzyme Q10 in Aging — María Elena Díaz-Casado, José Luis Quiles, Eliana Barriocanal‐Casado et al. Nutrients, 2019, unknown, 81 citations · DOI: 10.3390/nu11092221
  53. Pharmacological strategies to lower crosstalk between nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and mitochondria — Nirmala Koju, Abdoh Taleb, Jifang Zhou et al. Biomedicine & Pharmacotherapy, 2019, unknown, 67 citations · DOI: 10.1016/j.biopha.2018.11.128
  54. The usefulness of melatonin in the field of obstetrics and gynecology. — Genario R, Morello E, Bueno AA et al. Pharmacological research, 2019, systematic review, 33 citations · DOI: 10.1016/j.phrs.2019.104337
  55. Dehydroepiandrosterone Supplementation Improves the Outcomes of in vitro Fertilization Cycles in Older Patients With Diminished Ovarian Reserve — San‐Nung Chen, Kuan‐Hao Tsui, Peng‐Hui Wang et al. Frontiers in Endocrinology, 2019, cohort, 27 citations · DOI: 10.3389/fendo.2019.00800
  56. The Effect of Dehydroepiandrosterone (DHEA) Supplementation on IVF or ICSI: A Meta-Analysis of Randomized Controlled Trials — Lin Xu, Chunxia Hu, Qun Liu et al. Geburtshilfe und Frauenheilkunde, 2019, systematic review, 22 citations · DOI: 10.1055/a-0882-3791
  57. Generations of Fertility: A Bioethical and Evolutionary Analysis — Kat Panos Scholarly and Creative Works from DePauw University (DePauw University), 2019
  58. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial — Yang-Ying Xu, Victoria Nisenblat, Cuiling Lu et al. Reproductive Biology and Endocrinology, 2018, rct, 244 citations · DOI: 10.1186/s12958-018-0343-0
  59. Assessing imprecision in Cochrane systematic reviews: a comparison of GRADE and Trial Sequential Analysis — Greta Castellini, Matteo Bruschettini, Silvia Gianola et al. Systematic Reviews, 2018, systematic review, 159 citations · DOI: 10.1186/s13643-018-0770-1
  60. Oocyte in vitro maturation: A sytematic review — Şafak Hatırnaz, Barış Ata, Ebru Saynur Hatırnaz et al. Journal of Turkish Society of Obstetric and Gynecology, 2018, systematic review, 94 citations · DOI: 10.4274/tjod.23911
  61. Inositol for subfertile women with polycystic ovary syndrome. — Showell MG, Mackenzie-Proctor R, Jordan V et al. The Cochrane database of systematic reviews, 2018, meta analysis, 75 citations · DOI: 10.1002/14651858.cd012378.pub2
  62. Effects of myo-inositol plus alpha-lactalbumin in myo-inositol-resistant PCOS women — Mario Montanino Oliva, Giovanna Buonomo, Marco Calcagno et al. Journal of Ovarian Research, 2018, cohort, 62 citations · DOI: 10.1186/s13048-018-0411-2
  63. Sex/gender reporting and analysis in Campbell and Cochrane systematic reviews: a cross-sectional methods study — Jennifer Petkovic, Jessica Trawin, Omar Dewidar et al. Systematic Reviews, 2018, systematic review, 44 citations · DOI: 10.1186/s13643-018-0778-6
  64. Immune Regulation: The Possible Mechanism by which Dehydroepiandrosterone Improves Ovarian Reserve in Patients Having Diminished Ovarian Reserve (Dor) — Kulvinder Kochar Kaur, Gautam Allahbadia, Mandeep Singh Archives of Reproductive Medicine and Sexual Health, 2018 · DOI: 10.22259/2639-1791.0101002
  65. Role of Antioxidants in Assisted Reproductive Techniques — Ashok Kumar Agarwal, Ahmad A. Majzoub The World Journal of Men s Health, 2017, unknown, 105 citations · DOI: 10.5534/wjmh.2017.35.2.77
  66. The effect of dehydroepiandrosterone supplementation on ovarian response is associated with androgen receptor in diminished ovarian reserve women — Qiaofei Hu, Liming Hong, Mingyue Nie et al. Journal of Ovarian Research, 2017, cohort, 54 citations · DOI: 10.1186/s13048-017-0326-3
  67. Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials — Vittorio Unfer, John E. Nestler, Zdravko Asenov Kamenov et al. International Journal of Endocrinology, 2016, systematic review, 151 citations · DOI: 10.1155/2016/1849162
  68. Equilibrium between anti‐oxidants and reactive oxygen species: a requisite for oocyte development and maturation — Manika Kala, Muhammad Vaseem Shaikh, Manish Nivsarkar Reproductive Medicine and Biology, 2016, systematic review, 146 citations · DOI: 10.1002/rmb2.12013
  69. How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin — Salvatore Giovanni Vitale, Paola Rossetti, Francesco Corrado et al. International Journal of Endocrinology, 2016, unknown, 75 citations · DOI: 10.1155/2016/4987436
  70. The role of the androgen receptor and hydroxysteroid 17β dehydrogenase in breast cancer : Impact on tamoxifen treatment — Erik Hilbron Linköping University medical dissertations, 2016 · DOI: 10.3384/diss.diva-132453
  71. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging — Assaf Ben‐Meir, Eliezer Burstein, Aluet Borrego Alvarez et al. Aging Cell, 2015, animal, 470 citations · DOI: 10.1111/acel.12368
  72. A meta‐analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection — Jie Li, Hua Yuan, Yang Chen et al. International Journal of Gynecology & Obstetrics, 2015, meta analysis, 54 citations · DOI: 10.1016/j.ijgo.2015.06.028
  73. SIRT7 Exhibits Oncogenic Potential in Human Ovarian Cancer Cells. — Wang HL, Lu RQ, Xie SH et al. Asian Pacific journal of cancer prevention : APJCP, 2015, in vitro, 50 citations · DOI: 10.7314/apjcp.2015.16.8.3573
  74. Dehydroepiandrosterone improves the ovarian reserve of women with diminished ovarian reserve and is a potential regulator of the immune response in the ovaries — Jiali Zhang, Xuemin Qiu, Yuyan Gui et al. BioScience Trends, 2015, 28 citations · DOI: 10.5582/bst.2015.01154
  75. Effects of Exercise During Gestation on Maternal and Foetal Health Universidad de Granada, 2015, rct
  76. Molecular regulation of adrenal androgen biosynthesis — Jan Idkowiak University of Birmingham Institutional Research Archive (University of Birmingham), 2015
  77. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials — Evropi Τheodoratou, Ioanna Tzoulaki, Lina Zgaga et al. BMJ, 2014, systematic review, 956 citations · DOI: 10.1136/bmj.g2035
  78. Dehydroepiandrosterone (DHEA)Supplementation Pre-IVF(In Vitro Fertilization) Cycles ShangHai Ji Ai Genetics & IVF Institute, 2014, rct
  79. The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders ShangHai Ji Ai Genetics & IVF Institute, 2014, rct
  80. Aneuploidy Rates in Advanced Maternal Age Patients Supplemented With Coenzyme Q10 (CoQ10) Versus Those That Are Not: a Pilot Study Reproductive Endocrinology Associates of Charlotte, 2014, rct
  81. Lifestyle factors and reproductive health: taking control of your fertility — Rakesh Kumar Sharma, Kelly R Biedenharn, Jennifer Fedor et al. Reproductive Biology and Endocrinology, 2013, systematic review, 846 citations · DOI: 10.1186/1477-7827-11-66
  82. Efficacy of dehydroepiandrosterone to improve ovarian response in women with diminished ovarian reserve: a meta-analysis — Amarin Narkwichean, Walid E. Maalouf, Bruce K Campbell et al. Reproductive Biology and Endocrinology, 2013, systematic review, 86 citations · DOI: 10.1186/1477-7827-11-44
  83. Ototoxic Model of Oxaliplatin and Protection from Nicotinamide Adenine Dinucleotide — Ding Dalian, Jiang Haiyan, Yong Fu et al. Journal of Otology, 2013, 12 citations · DOI: 10.1016/s1672-2930(13)50009-2
  84. Lipid nanoparticles encapsulating siRNAs against the androgen receptor to treat advanced prostate cancer — Justin Barry Lee cIRcle (University of British Columbia), 2013 · DOI: 10.14288/1.0073915
  85. The role of melatonin as an antioxidant in the follicle — Hiroshi Tamura, Akihisa Takasaki, Toshiaki Taketani et al. Journal of Ovarian Research, 2012, systematic review, 276 citations · DOI: 10.1186/1757-2215-5-5
  86. Androgens, diabetes and prostate cancer — Mathis Grossmann, Gary Wittert Endocrine Related Cancer, 2012, systematic review, 77 citations · DOI: 10.1530/erc-12-0067
  87. Co Enzyme Q10 Improves IVF Outcome in With Advanced Reproductive Age Hadassah Medical Organization, 2012, rct
  88. Effect of Dehydroepiandrosterone Administration in Patients With Poor Ovarian Response According to the Bologna Criteria Chinese Medical Association, 2011, cohort
  89. Invited review: Use of meta-analysis in animal health and reproduction: Methods and applications — I.J. Lean, A.R. Rabiee, T.F. Duffield et al. Journal of Dairy Science, 2009, systematic review, 257 citations · DOI: 10.3168/jds.2009-2140
  90. How Dose Coenzyme Q10 Supplementation During Infertility Treatment Effects Pregnancy Outcome University of Toronto, 2009, rct
  91. Dehydroepiandrosterone Supplementation for Poor Responder Patients During in Vitro Fertilization Treatment Meir Medical Center, 2008, rct
  92. DHEA Supplementation for Low Ovarian Response IVF Patients Shaare Zedek Medical Center, 2008, rct
  93. Review Article - Interrelationship between Androgen Levels, Ageing, andCognitive Functions — Hanumanthachar Joshi, Milind Parle TSpace (University of Toronto), 2007
  94. Androgens and Coronary Artery Disease — Fredrick C. W. Wu, Arnold von Eckardstein Humana Press eBooks, 2003, 9 citations · DOI: 10.1007/978-1-59259-388-0_10