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Library / Natural & Life Sciences / Medicine, Health & Longevity / Reproductive Medicine & Human Fertility / Advanced Maternal Age & Pregnancy After 40

Antiplatelet Prophylaxis Dosing & Gestational Timing

Dose-response efficacy (75–162 mg), gestational initiation window, platelet responsiveness, and perinatal outcomes of aspirin prophylaxis.

16 sources ↓Last researched 2026-10-16

State of the Field: Antiplatelet Prophylaxis Dosing & Gestational Timing

Dose-response efficacy (75–162 mg), gestational initiation window, platelet responsiveness, and perinatal outcomes of aspirin prophylaxis. Grounded synthesis across 16 primary sources and 5 graded findings within Reproductive Medicine & Human Fertility → Advanced Maternal Age & Pregnancy After 40.

Synopsis · Executive Overview

Antiplatelet Prophylaxis Dosing & Gestational Timing is a canonical branch of the library within Natural & Life Sciences › Medicine, Health & Longevity › Reproductive Medicine & Human Fertility › Advanced Maternal Age & Pregnancy After 40 › Pre-eclampsia Pathophysiology, Biomarkers & Prophylaxis, investigating dose-response efficacy (75–162 mg), gestational initiation window, platelet responsiveness, and perinatal outcomes of aspirin prophylaxis. Spanning published milestones from 1978 to 2026, the indexed dossier currently comprises 16 primary sources and 5 graded findings.

Section I · Primary Literature & Evidence Synthesis

What the Peer-Reviewed Record Establishes

The primary research record in Antiplatelet Prophylaxis Dosing & Gestational Timing is stratified by study design so that meta-analyses and replicated randomised controlled trials (T1–T2) carry greater epistemic weight than observational cohorts (T3–T4) or preclinical laboratory work (T5). Leading graded findings establish the core empirical baseline: [T3] This study aimed to explore midwives’ lived experiences and clinical competence in implementing low-dose aspirin prophylaxis for preeclampsia prevention. [3] [T3] INTRODUCTION: Pregnancies resulting from in vitro fertilisation are associated with an increased risk of developing hypertensive disorders of pregnancy, such as preeclampsia, when compared with naturally conceived pregnancies. [9]

Further clinical and mechanistic stratification across the literature demonstrates: [T3] Preeclampsia (PE) is a multifactorial hypertensive disorder of pregnancy and a leading cause of maternal and perinatal morbidity and mortality worldwide. [4] [T3] Background: Preeclampsia is a hypertensive disorder of pregnancy affecting approximately 4% of pregnancies, contributing significantly to maternal and perinatal morbidity . [6]

Section II · Mechanisms, Interventions & Subgroup Calibration

Comparative Evaluation of Levers & Theoretical Models

Within Reproductive Medicine & Human Fertility → Advanced Maternal Age & Pregnancy After 40, mechanistic and clinical evaluation in Antiplatelet Prophylaxis Dosing & Gestational Timing focuses on dose-response efficacy (75–162 mg), gestational initiation window, platelet responsiveness, and perinatal outcomes of aspirin prophylaxis. Primary publications in the current corpus span Scientific Reports, Journal of Medicine and Palliative Care, International Journal of Contemporary Sciences, Cureus.

Section III · Historical Trajectory & Contested Frontiers

Evolution of the Field, Open Debates & Active Trials

Chronologically, the field evolved through key inflection points: in 1978, Human Fertility: The Basic Components. (In this innovative and comprehensive work, expanded by one-third for the English-language edition, Henri Leridon integrates biology and demography to investigate human fertility, both natural and controlled); in 2017, Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia (It is uncertain whether the intake of low-dose aspirin during pregnancy reduces the risk of preterm preeclampsia); in 2020, PREVENTION OF PREECLAMPSIA IN WOMEN WITH MULTIPLE PREGNANCY AFTER ASSISTED REPRODUCTION (Materials and methods: Clinical and laboratory prospective analysis of 54 cases of twins in women, treated from infertility with assisted reproductive technologies (ART), using the method of intracytoplasmic sperm injection (ICSI) and frozen embryos transfer, have been made); in 2026, Prevalence of Gestational Diabetes Mellitus and Its Associated Risk Factors Among Pregnant Women Attending a… (BackgroundGestational diabetes mellitus (GDM) is an increasingly important public health problem associated with adverse maternal and fetal outcomes).

Section IV · Evidentiary Gaps & Research Frontiers

Open Questions & Priorities for the Next Research Sweep

Methodological priorities and open empirical questions queued for the next research sweep across Antiplatelet Prophylaxis Dosing & Gestational Timing focus on resolving subgroup effect sizes, causal mechanisms, and long-term outcomes:

  • Deeper primary-source synthesis and systematic sub-branch expansion across Antiplatelet Prophylaxis Dosing & Gestational Timing.
  • Cross-disciplinary replication and empirical tests of frontier hypotheses within Antiplatelet Prophylaxis Dosing & Gestational Timing.

Evidence Hierarchy (Graded Claims)

  • T1Synthesis of trials
    0 (0%)
  • T2Randomised trial
    0 (0%)
  • T3Observational, large
    5 (100%)
  • T4Observational, small or case-based
    0 (0%)
  • T5Preclinical or mechanistic
    0 (0%)
  • T6Opinion, news or unverified
    0 (0%)
5 settled0 debated0 contested / frontier

Study Designs in Indexed Literature

  • Meta-analyses, Systematic Reviews & Guidelines2 (13%)
  • Randomised Controlled Trials (RCTs)2 (13%)
  • Prospective Cohorts & Clinical Registries3 (19%)
  • Observational & Clinical Case Series1 (6%)
  • Preclinical, Cellular & Computational Models3 (19%)
  • Primary Literature & Archive Records5 (31%)

Publication Timeline Velocity

Fig. 1 — Field Evidence Architecture & Publication Trajectory. Distribution of methodological study designs (16 indexed publications) and 5 extracted claims graded from T1 (meta-analyses and guidelines) to T6.
Primary Citations & Landmark Studies

Key Studies Anchoring This Monograph

Synthesis & Conclusions

State of the Field Conclusions

Taken together, the evidence record in Antiplatelet Prophylaxis Dosing & Gestational Timing (16 primary sources, 5 graded claims, highest certainty T3 — Observational, large) separates replicated high-tier findings from early-stage hypotheses. The 2 open research priorities detailed above guide the next autonomous literature and clinical trial sweep.

Key Quantitative Takeaways

  • [T3] This study aimed to explore midwives’ lived experiences and clinical competence in implementing low-dose aspirin prophylaxis for preeclampsia prevention.
  • [T3] INTRODUCTION: Pregnancies resulting from in vitro fertilisation are associated with an increased risk of developing hypertensive disorders of pregnancy, such as preeclampsia, when compared with naturally conceived pregnancies.
  • [T3] Preeclampsia (PE) is a multifactorial hypertensive disorder of pregnancy and a leading cause of maternal and perinatal morbidity and mortality worldwide.
  • [T3] Background: Preeclampsia is a hypertensive disorder of pregnancy affecting approximately 4% of pregnancies, contributing significantly to maternal and perinatal morbidity .
  • Open frontier in Antiplatelet Prophylaxis Dosing & Gestational Timing: Deeper primary-source synthesis and systematic sub-branch expansion across Antiplatelet Prophylaxis Dosing & Gestational Timing.
Historical timeline (4 milestones, 1978–2026)
  1. 1978

    Human Fertility: The Basic Components.

    In this innovative and comprehensive work, expanded by one-third for the English-language edition, Henri Leridon integrates biology and demography to investigate human fertility, both natural and controlled.

  2. 2017

    Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

    It is uncertain whether the intake of low-dose aspirin during pregnancy reduces the risk of preterm preeclampsia.

  3. 2020

    PREVENTION OF PREECLAMPSIA IN WOMEN WITH MULTIPLE PREGNANCY AFTER ASSISTED REPRODUCTION

    Materials and methods: Clinical and laboratory prospective analysis of 54 cases of twins in women, treated from infertility with assisted reproductive technologies (ART), using the method of intracytoplasmic sperm injection (ICSI) and frozen embryos transfer, have been made.

  4. 2026

    Prevalence of Gestational Diabetes Mellitus and Its Associated Risk Factors Among Pregnant Women Attending a…

    BackgroundGestational diabetes mellitus (GDM) is an increasingly important public health problem associated with adverse maternal and fetal outcomes.

Evidence by study design (5 findings across T1–T6)

Strongest support first. The bar beside each finding shows its grade.

Observational, large

  1. #1 This study aimed to explore midwives’ lived experiences and clinical competence in implementing low-dose aspirin prophylaxis for preeclampsia prevention.

    Exploring Midwives’ Lived Experience and Competence in Low-Dose Aspi… (2026)

    Extracted from primary literature (2026).

  2. #2 INTRODUCTION: Pregnancies resulting from in vitro fertilisation are associated with an increased risk of developing hypertensive disorders of pregnancy, such as preeclampsia, when compared with naturally conceived pregnancies.

    Low-dose aspirin prophylaxis to prevent hypertensive disorders of pr… (2024)

    Extracted from primary literature (2024).

  3. #3 Preeclampsia (PE) is a multifactorial hypertensive disorder of pregnancy and a leading cause of maternal and perinatal morbidity and mortality worldwide.

    Prophylaxis of Preeclampsia With Low-Dose Aspirin: A Comprehensive R… (2025)

    Extracted from primary literature (2025).

  4. #4 Background: Preeclampsia is a hypertensive disorder of pregnancy affecting approximately 4% of pregnancies, contributing significantly to maternal and perinatal morbidity .

    ASPIRIN FOR PRE-ECLAMPSIA PREVENTION: A SYSTEMATIC REVIEW OF DOSE AN… (2025)

    Extracted from primary literature (2025).

  5. #5 Guideline-based eligibility (≥1 high-risk or ≥2 moderate-risk factors), prescription, timing of initiation (≤16 weeks, >16 weeks, not started), and dose were abstracted from medical records.

    Eligibility, timing, and outcomes of low-dose aspirin prophylaxis in… (2026)

    Extracted from primary literature (2026).

Node lineage & crossover disciplines

Parent lineage, active node, direct child sub-branches, and associated crossover disciplines across the Tree of Knowledge.

Hierarchy:
Natural & Life SciencesMedicine, Health & LongevityReproductive Medicine & Human FertilityAdvanced Maternal Age & Pregnancy After 40Antiplatelet Prophylaxis Dosing & Gestational TimingLeaf node (no child sub-branches yet)
+ Associated nodes:

Branches

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Primary indexed sources (16)

Primary scientific literature, systematic reviews, and clinical trial registrations indexed for this branch.

  1. Early initiation of low-dose aspirin for the prevention of pre-eclampsia in high-risk pregnancies — Fahad T. Alsulami, Eman Mostafa Hamed Scientific Reports, 2026, rct, 2 citations · DOI: 10.1038/s41598-025-28078-3
  2. Eligibility, timing, and outcomes of low-dose aspirin prophylaxis in pregnancy at risk of preeclampsia: a retrospective cohort study — Resat Misirlioglu, Ali Çetin Journal of Medicine and Palliative Care, 2026, cohort · DOI: 10.47582/jompac.1963369
  3. Exploring Midwives’ Lived Experience and Competence in Low-Dose Aspirin Prophylaxis for Preeclampsia Prevention — Sendy Dwi Pertiwi, Al-Munawir, Tecky Indriana International Journal of Contemporary Sciences, 2026, expert opinion · DOI: 10.55927/y8bp3q08
  4. Prophylaxis of Preeclampsia With Low-Dose Aspirin: A Comprehensive Review — Hira Sohail Cureus, 2025, expert opinion, 2 citations · DOI: 10.7759/cureus.96529
  5. Supplementary Information from Efficacy and Safety of the Anti–PD-L1 mAb Socazolimab for Recurrent or Metastatic Cervical Cancer: a Phase I Dose-Escalation and Expansion Study — Jusheng An, Jie Tang, Xiaoyi Li et al. 2025, expert opinion · DOI: 10.1158/1078-0432.30706035
  6. ASPIRIN FOR PRE-ECLAMPSIA PREVENTION: A SYSTEMATIC REVIEW OF DOSE AND TIMING EFFECTIVENESS — Anisha Kaur Sethi PARIPEX-INDIAN JOURNAL OF RESEARCH, 2025, systematic review · DOI: 10.36106/paripex/3600510
  7. Effect of intraovarian platelet-rich plasma injection on IVF outcomes in women with poor ovarian response: the PROVA randomized controlled trial — Nola S. Herlihy, Yiğit Çakıroğlu, Christine V. Whitehead et al. Human Reproduction, 2024, rct, 38 citations · DOI: 10.1093/humrep/deae093
  8. Role of Antiplatelets and Anticoagulation Therapies in Pregnancy — K Varghese Zachariah, Su Yuan, Maria Teresa DeSancho et al. Journal of Clinical Medicine, 2024, guideline, 11 citations · DOI: 10.3390/jcm13247757
  9. Low-dose aspirin prophylaxis to prevent hypertensive disorders of pregnancy after in vitro fertilisation: a scoping review protocol — Julie Collée, Julie Vervier, Sandrina Vandenput et al. BMJ Open, 2024, in vitro, 2 citations · DOI: 10.1136/bmjopen-2023-080353
  10. Efficacy of Uterine Artery Doppler Changes, Platelet Indices and Combination of Both in Prediction of Preeclampsia in Pregnant Women: A Prospective Observational Study — Firdous Fatima, Sangeeta Shah, Sangeeta Shah et al. International Journal of Anatomy Radiology and Surgery, 2024, cohort · DOI: 10.7860/ijars/2024/73209.3025
  11. Efficacy of low-dose hCG on FET cycle in patients with recurrent implantation failure — Xinyu Zhai, Mingming Shu, Yiming Guo et al. Frontiers in Endocrinology, 2022, cohort, 3 citations · DOI: 10.3389/fendo.2022.1053592
  12. Assessment of the consequences of gestational SSRI antidepressant exposure in the rat — DeSanctis, Natalie Ann Arrow@dit (Dublin Institute of Technology), 2019, expert opinion · DOI: 10.13025/16852
  13. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery — Alan Tita, Jeff M. Szychowski, Kim Boggess et al. New England Journal of Medicine, 2016, expert opinion, 288 citations · DOI: 10.1056/nejmoa1602044
  14. Structural and functional aspects of factor viii in the initiation of the anti-factor viii immune response — Bagirath Gangadharan 2014, in vitro, 1 citations · DOI: 10.70675/3b30a350z8718z49b3z9fd9z69d7cc29ff8d
  15. Role of Platelet-Derived Growth Factors in the Testis — Sabrina Basciani, Stefania Mariani, Giovanni Spera et al. Endocrine Reviews, 2010, animal, 99 citations · DOI: 10.1210/er.2010-0004
  16. Spinal–Epidural Hematoma following Epidural Anesthesia in the Presence of Antiplatelet and Heparin Therapy — Rainer J. Litz, Matthias Hübler, Thea Koch et al. Anesthesiology, 2001, case series, 49 citations · DOI: 10.1097/00000542-200110000-00039