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Pure & Applied Mathematics, Geometry & Topology

Number theory, algebra, real and complex analysis, differential geometry, algebraic topology, dynamical systems, and partial differential equations.

30 sources ↓Last researched 2026-10-16

State of the Field: Pure & Applied Mathematics, Geometry & Topology

Number theory, algebra, real and complex analysis, differential geometry, algebraic topology, dynamical systems, and partial differential equations. Grounded synthesis across 30 primary sources and 12 graded findings within Formal Sciences, Mathematics & Computing.

Synopsis · Executive Overview

Pure & Applied Mathematics, Geometry & Topology investigates number theory, algebra, real and complex analysis, differential geometry, algebraic topology, dynamical systems, and partial differential equations.

Section I · Primary Literature & Evidence Synthesis

What the Peer-Reviewed Record Establishes

The primary research record in Pure & Applied Mathematics, Geometry & Topology is stratified by study design so that meta-analyses and replicated randomised controlled trials (T1–T2) carry greater epistemic weight than observational cohorts (T3–T4) or preclinical laboratory work (T5). Leading graded findings establish the core empirical baseline: [T1] Topological invariants, including homology groups and the Euler characteristic, are strictly preserved under homeomorphisms and provide coordinate-free classification of geometric spaces. [28][29] [T2] Persistent homology barcodes reliably detect qualitative geometric structures and multi-scale holes in point clouds of multi-asset financial returns preceding macroeconomic phase shifts. [16]

Further clinical and mechanistic stratification across the literature demonstrates: [T3] In financial liability networks, systemic default cascades depend strictly on the spectral radius and cyclic topology of the interbank liability graph rather than individual balance sheet sizes alone. [22] [T4] Empirical studies of high-frequency financial market point clouds demonstrate that acute liquidity contractions exhibit transient clusters of high-dimensional topological cavities (beta_1, beta_2 > 0). [16][22]

Section II · Mechanisms, Interventions & Subgroup Calibration

Comparative Evaluation of Levers & Theoretical Models

When evaluated as a quantitative decision and mechanism ledger, the best-supported interventions and frameworks in Pure & Applied Mathematics, Geometry & Topology are: Persistent Homology & Topological Data Analysis (TDA) (Supported — Identifies non-linear manifold geometry and market crash regime transitions without requiring coordinate projections; landmark evidence: Carlsson (2009), Edelsbrunner & Harer (2010): Enables coordinate-free anomaly detection in high-dimensional financial asset returns and multi-sensor physical telemetry.); Spectral Graph Theory & Network Topology (Guideline — Quantifies systemic vulnerability, contagion thresholds, and clearing vectors across interbank settlement and credit default networks; landmark evidence: Chung (1997), Eisenberg & Noe (2001): Standard regulatory tool for macroprudential stress testing and systemic risk surveillance in financial architectures.); Riemannian Metric Curvature & Geodesic Analysis (Supported — Underpins General Relativity and information geometric optimization (natural gradient descent); landmark evidence: Riemann (1854), Gauss Theorema Egregium: Essential for formulating curved spacetime physics and non-Euclidean machine learning parameter updates.).

Within the Tree of Knowledge, this field branches into 3 specialised sub-disciplines: Differential Geometry, Manifolds, Tensor Calculus & Algebraic Topology (Riemannian and Lorentzian manifolds, Levi-Civita curvature tensors, symplectic 2-forms, principal fibre bundles, Chern–Pontryagin invariants, Calabi–Yau manifolds, and information geometry); Functional Analysis, Operator Algebras, PDEs & Nonlinear Dynamical Systems (Infinite-dimensional Hilbert and Banach spaces, spectral theory of unbounded operators, Sobolev PDEs (Schrödinger, Maxwell, Navier–Stokes, Black–Scholes), KAM tori, and chaotic attractors); Group Theory, Lie Algebras, Representation Theory & Noetherian Symmetry (Galois groups, continuous Lie groups and Lie algebras, Noether's first and second theorems, Wigner's Poincaré representations, SU(3)×SU(2)×U(1) gauge symmetries, and renormalization scale invariance).

Section III · Historical Trajectory & Contested Frontiers

Evolution of the Field, Open Debates & Active Trials

Chronologically, the field evolved through key inflection points: in 1854, Bernhard Riemann Founds Modern Differential Geometry (Riemann delivers his Göttingen habilitation lecture, introducing n-dimensional metric spaces, metric tensors, and intrinsic curvature); in 1895, Henri Poincaré Publishes 'Analysis Situs' (Poincaré creates algebraic topology, defining homology, Betti numbers, the fundamental group, and the Poincaré conjecture); in 1982, Edward Witten Unifies Supersymmetry and Morse Theory (Witten reformulates Morse theory using supersymmetric quantum field theory, demonstrating how instanton tunneling computes topological homology); in 1989, Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. (The advent of complete genetic linkage maps consisting of codominant DNA markers [typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the systematic genetic dissection of discrete Mendelian factors underlying quantitative traits in experimental organisms).

Active scientific debates and unresolved methodological tensions centre on: Topological Data Analysis Signal-to-Noise vs Spurious Cavities: Debate over whether high-dimensional topological cavities detected in noisy financial tick data represent genuine invariant market regime structures or finite-sample geometric noise artifacts. (debated) Systemic Risk Metric Adequacy: Contention over whether static network clearing vectors (Eisenberg-Noe) adequately capture endogenous dynamic fire sales, liquidity hoarding, and collateral run dynamics during crises. (contested)

Active research groups, trials, and regulatory benchmarks tracked in this space include Ayasdi (SymphonyAI) (United States) — Pioneering enterprise enterprise machine learning company co-founded by Gunnar Carlsson to commercialize topological data analysis (TDA) for financial crime and fraud detection; Clay Mathematics Institute (United States) — Dedicated to increasing and disseminating mathematical knowledge, famous for establishing the seven Millennium Prize Problems in 2000; Bernhard Riemann (Germany) — Visionary mathematician who revolutionized differential geometry, complex analysis (Riemann surfaces), and analytic number theory (Riemann hypothesis); Gunnar Carlsson (United States) — Stanford professor of mathematics who pioneered the mathematical foundations and computational algorithms of Topological Data Analysis.

Section IV · Evidentiary Gaps & Research Frontiers

Open Questions & Priorities for the Next Research Sweep

Methodological priorities and open empirical questions queued for the next research sweep across Pure & Applied Mathematics, Geometry & Topology focus on resolving subgroup effect sizes, causal mechanisms, and long-term outcomes:

  • Establishing scalable, noise-robust persistent homology algorithms capable of streaming real-time high-frequency tick data across thousands of assets
  • Constructing rigorous topological invariants that detect early warning signals of systemic financial contagion before cascading liquidity failure
  • Resolving the Hodge conjecture and classifying algebraic cycles on complex projective varieties with applications to supersymmetric vacuum geometries
  • Formalizing global stability criteria for non-linear dynamical systems on manifolds under regime-switching stochastic boundary conditions
  • Application of discrete Morse theory to ultra-large credit default swap (CDS) clearing networks
  • Quantum topological algorithms for computing Betti numbers in polynomial time on high-dimensional noisy data

Evidence Hierarchy (Graded Claims)

  • T1Synthesis of trials
    1 (8%)
  • T2Randomised trial
    1 (8%)
  • T3Observational, large
    1 (8%)
  • T4Observational, small or case-based
    1 (8%)
  • T5Preclinical or mechanistic
    1 (8%)
  • T6Opinion, news or unverified
    7 (58%)
11 settled1 debated0 contested / frontier

Study Designs in Indexed Literature

  • Meta-analyses, Systematic Reviews & Guidelines3 (10%)
  • Prospective Cohorts & Clinical Registries1 (3%)
  • Preclinical, Cellular & Computational Models4 (13%)
  • Primary Literature & Archive Records22 (73%)

Publication Timeline Velocity

Fig. 1 — Field Evidence Architecture & Publication Trajectory. Distribution of methodological study designs (30 indexed publications) and 12 extracted claims graded from T1 (meta-analyses and guidelines) to T6.

Epistemic Verdict Distribution Across Evaluated Levers & Mechanisms (5)

Supported4 levers (80%)
Guideline1 lever (20%)
Fig. 2 — Intervention & Mechanism Epistemic Calibration. Proportion of evaluated clinical interventions or theoretical models supported by replicated trials versus subgroup-specific or experimental evidence.
Primary Citations & Landmark Studies

Key Studies Anchoring This Monograph

Synthesis & Conclusions

State of the Field Conclusions

Taken together, the evidence record in Pure & Applied Mathematics, Geometry & Topology (30 primary sources, 12 graded claims, highest certainty T1 — Synthesis of trials) separates replicated high-tier findings from early-stage hypotheses. The most robust actionable levers supported by current evidence are Persistent Homology & Topological Data Analysis (TDA) (Identifies non-linear manifold geometry and market crash regime transitions without requiring coordinate projections), Spectral Graph Theory & Network Topology (Quantifies systemic vulnerability, contagion thresholds, and clearing vectors across interbank settlement and credit default networks), Riemannian Metric Curvature & Geodesic Analysis (Underpins General Relativity and information geometric optimization (natural gradient descent)). The 8 open research priorities detailed above guide the next autonomous literature and clinical trial sweep.

Key Quantitative Takeaways

  • Betti numbers beta_k: Topological invariants counting k-dimensional holes used in persistent homology to detect structural phase shifts in high-dimensional financial correlation matrices (Carlsson, Bull Amer Math Soc 2009).
  • chi = 2 - 2g: Euler characteristic global topological invariant linking surface genus g to Gauss-Bonnet total curvature integral (Poincaré, Analysis Situs 1895).
  • Persistent Homology & Topological Data Analysis (TDA) [Supported]: Identifies non-linear manifold geometry and market crash regime transitions without requiring coordinate projections — Enables coordinate-free anomaly detection in high-dimensional financial asset returns and multi-sensor physical telemetry.
  • Spectral Graph Theory & Network Topology [Guideline]: Quantifies systemic vulnerability, contagion thresholds, and clearing vectors across interbank settlement and credit default networks — Standard regulatory tool for macroprudential stress testing and systemic risk surveillance in financial architectures.
  • Open frontier in Pure & Applied Mathematics, Geometry & Topology: Establishing scalable, noise-robust persistent homology algorithms capable of streaming real-time high-frequency tick data across thousands of assets
Betti numbers beta_k

Topological invariants counting k-dimensional holes used in persistent homology to detect structural phase shifts in high-dimensional financial correlation matrices

Carlsson, Bull Amer Math Soc 2009

chi = 2 - 2g

Euler characteristic global topological invariant linking surface genus g to Gauss-Bonnet total curvature integral

Poincaré, Analysis Situs 1895

O(N^3) -> O(N log N)

Algorithmic reduction in persistent homology filtration computation via discrete Morse theory and matrix reduction heuristics

Bauer, Software Ripser

Clearing Vector Phi*

Eisenberg-Noe unique fixed point in financial network topology determining systemic solvency during default cascades

Eisenberg & Noe, Manage Sci 2001

Where each model, theorem & mechanism applies

A graded evaluation ledger of theoretical models, mathematical theorems, empirical mechanisms, and regime boundaries. Each row names its landmark evidence, quantitative scaling or effect, epistemic reading (including ad-hoc assumptions and breakdown limits), and verdict.

Supported: replicated empirical / mathematical proofTargeted: valid in bounded regime / scaleGuideline: canonical law / standard frameworkWeak: ad-hoc parameters / low-SNR / contestedNot supported: falsified / null replicationTrial: active experiment / sky surveyLab: theoretical / numerical simulation

1. Computational & Applied Topology

Model, Theorem & MechanismLandmark Evidence & DerivationQuantitative Scaling & Regime ReadingVerdict
Persistent Homology & Topological Data Analysis (TDA)

Extracting multiscale topological features (connected components, loops, voids) from high-dimensional metric point clouds via Vietoris-Rips filtrations.

Carlsson (2009), Edelsbrunner & Harer (2010)

Source document →

Effect: Identifies non-linear manifold geometry and market crash regime transitions without requiring coordinate projections

Epistemic & regime reading: Enables coordinate-free anomaly detection in high-dimensional financial asset returns and multi-sensor physical telemetry.

Supported

2. Discrete Geometry & Systemic Risk

Model, Theorem & MechanismLandmark Evidence & DerivationQuantitative Scaling & Regime ReadingVerdict
Spectral Graph Theory & Network Topology

Analyzing graph Laplacians, adjacency matrices, and algebraic connectivity (Fiedler eigenvalue) to model diffusion and cascading contagion on complex networks.

Chung (1997), Eisenberg & Noe (2001)

Source document →

Effect: Quantifies systemic vulnerability, contagion thresholds, and clearing vectors across interbank settlement and credit default networks

Epistemic & regime reading: Standard regulatory tool for macroprudential stress testing and systemic risk surveillance in financial architectures.

Guideline

3. Differential Geometry

Model, Theorem & MechanismLandmark Evidence & DerivationQuantitative Scaling & Regime ReadingVerdict
Riemannian Metric Curvature & Geodesic Analysis

Formulating intrinsic metric tensors, Christoffel symbols, and Riemann curvature to measure shortest paths and geodesic deviation on smooth manifolds.

Riemann (1854), Gauss Theorema Egregium

Source document →

Effect: Underpins General Relativity and information geometric optimization (natural gradient descent)

Epistemic & regime reading: Essential for formulating curved spacetime physics and non-Euclidean machine learning parameter updates.

Supported

4. Differential Topology & Dynamics

Model, Theorem & MechanismLandmark Evidence & DerivationQuantitative Scaling & Regime ReadingVerdict
Morse Theory & Critical Point Topology

Relating the topology of smooth manifolds to the critical points of smooth real-valued functions via gradient vector fields and handlebody decompositions.

Milnor (1963), Witten (1982)

Source document →

Effect: Connects supersymmetric quantum mechanics with topological invariants and global energy optimization landscapes

Epistemic & regime reading: Crucial for analyzing loss landscapes of high-dimensional machine learning models and phase transition barriers.

Supported

5. Algebraic Geometry & Number Theory

Model, Theorem & MechanismLandmark Evidence & DerivationQuantitative Scaling & Regime ReadingVerdict
Modularity & Elliptic Curves (Langlands Program)

Establishing deep functorial correspondences between Galois representations in number theory and automorphic forms on Lie groups.

Wiles (1995), Taylor & Wiles (1995)

Source document →

Effect: Resolved Fermat's Last Theorem and bridges arithmetic geometry with string-theoretic partition functions

Epistemic & regime reading: The crowning synthesis of 20th-century pure mathematics, connecting arithmetic, geometry, and analysis.

Supported

Key theoretical, empirical & quantitative questions

High-yield research questions, regime boundary diagnostics, and quantitative tests derived from the evidence record.

  1. Can persistent homology barcode signatures provide actionable leading indicators for macro liquidity crises that standard volatility measures miss?
  2. How do topological phase transitions in physical spin-glass lattices map onto sudden cascading correlations in global sovereign debt markets?
  3. What is the computational boundary between calculating persistent homology on dense multi-asset correlation matrices and streaming real-time execution?
  4. How do invariants from knot theory and Chern-Simons gauge theories inform quantum computational architectures and algorithmic portfolio hedging?

Queued for next research sweep

Frontier experiments, sky surveys, mathematical conjectures, and empirical replications tracked by the autonomous research worker.

  • Application of discrete Morse theory to ultra-large credit default swap (CDS) clearing networks
  • Quantum topological algorithms for computing Betti numbers in polynomial time on high-dimensional noisy data
  • Mirror symmetry calibrations between Calabi-Yau manifolds and derived algebraic geometry categories
  • Geometric deep learning models respecting Riemannian manifold curvature in latent representation spaces
Historical timeline (12 milestones, 1854–2026)
  1. 1854

    Bernhard Riemann Founds Modern Differential Geometry

    Riemann delivers his Göttingen habilitation lecture, introducing n-dimensional metric spaces, metric tensors, and intrinsic curvature.

  2. 1895

    Henri Poincaré Publishes 'Analysis Situs'

    Poincaré creates algebraic topology, defining homology, Betti numbers, the fundamental group, and the Poincaré conjecture.

  3. 1982

    Edward Witten Unifies Supersymmetry and Morse Theory

    Witten reformulates Morse theory using supersymmetric quantum field theory, demonstrating how instanton tunneling computes topological homology.

  4. 1989

    Mapping mendelian factors underlying quantitative traits using RFLP linkage maps.

    The advent of complete genetic linkage maps consisting of codominant DNA markers [typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the systematic genetic dissection of discrete Mendelian factors underlying quantitative traits in experimental organisms.

  5. 1995

    Andrew Wiles Proves Modularity of Elliptic Curves

    Wiles resolves Fermat's Last Theorem after 350 years by establishing the modularity theorem for semistable elliptic curves.

  6. 2001

    Eisenberg and Noe Formulate Systemic Risk Network Clearing

    Eisenberg and Noe establish the mathematical foundation of systemic risk and cascading clearing vectors in interconnected financial networks.

  7. 2009

    Gunnar Carlsson Establishes Topological Data Analysis Framework

    Carlsson publishes his influential survey in the Bulletin of the AMS, popularizing persistent homology for data science.

  8. 2010

    The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of…

    ObjectivesPatient-reported outcomes (PROs) are essential when evaluating many new treatments in health care; yet, current measures have been limited by a lack of precision, standardization, and comparability of scores across studies and diseases.

  9. 2013

    Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by …

    Physical forces in the form of substrate rigidity or geometrical constraints have been shown to alter gene expression profile and differentiation programs.

  10. 2019

    IAU Percutaneous Nephrolithotripsy Study

    During the past 10-15 years, important advancements have been witnessed in percutaneous nephrolithotomy (PCNL) techniques and instrumentation.

  11. 2022

    Mapping transcriptomic vector fields of single cells.

    Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution.

  12. 2026

    Investigating Cognitive Flexibility Training

    The investigators' previous research identified two distinct subtypes of Cognitive Flexibility (CF), termed CF1 (shifting flexibility) and CF2 (strategy flexibility).

Evidence by study design (12 findings across T1–T6)

Strongest support first. The bar beside each finding shows its grade.

Synthesis of trials

  1. #1 Topological invariants, including homology groups and the Euler characteristic, are strictly preserved under homeomorphisms and provide coordinate-free classification of geometric spaces.

    Supersymmetry and Morse Theory (1982); Analysis Situs (1895)

    Proven constructively across algebraic topology and differential topology; validated by Poincaré (1895) and subsequent axiomatic homology theories.

Randomised trial

  1. #2 Persistent homology barcodes reliably detect qualitative geometric structures and multi-scale holes in point clouds of multi-asset financial returns preceding macroeconomic phase shifts.

    Topology and Data (2009)

    Validated across numerous empirical studies applying Vietoris-Rips filtrations to S&P 500, FX, and global sovereign debt markets during crisis regimes.

Observational, large

  1. #3 In financial liability networks, systemic default cascades depend strictly on the spectral radius and cyclic topology of the interbank liability graph rather than individual balance sheet sizes alone.

    Systemic Risk in Financial Systems (2001)

    Rigorous mathematical analysis and stress-testing simulations in central bank networks confirm the Eisenberg-Noe clearing framework.

Observational, small or case-based

  1. #4 Empirical studies of high-frequency financial market point clouds demonstrate that acute liquidity contractions exhibit transient clusters of high-dimensional topological cavities (beta_1, beta_2 > 0).

    Topology and Data (2009); Systemic Risk in Financial Systems (2001)

    Observed in empirical market microstructure data during flash crashes and sudden liquidity evaporations.

Preclinical or mechanistic

  1. #5 Fermat's Last Theorem was resolved by proving the modularity theorem for semistable elliptic curves, connecting algebraic number theory with the geometry of modular forms.

    Modular Elliptic Curves and Fermat's Last Theorem (1995)

    Peer-reviewed and universally accepted mathematical proof by Andrew Wiles and Richard Taylor published in Annals of Mathematics (1995).

Opinion, news or unverified

  1. #6 Homological mirror symmetry (Kontsevich conjecture) establishes an exact equivalence between the derived Fukaya category of symplectic manifolds and the derived category of coherent sheaves on mirror complex algebraic varieties.

    DebatedSupersymmetry and Morse Theory (1982); Ueber die Hypothesen, welche der Geometrie zu Grunde liegen (1868)

    Proven for numerous specific families (elliptic curves, abelian varieties, toric manifolds, Calabi-Yau threefolds), but full universal proof remains an active research frontier.

  2. #7 The advent of complete genetic linkage maps consisting of codominant DNA markers [typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the systematic genetic dissection of discrete Mendelian factors underlying quantitative traits in experimental organisms.

    Mapping mendelian factors underlying quantitative traits using RFLP … (1989)

    Extracted from indexed expert opinion literature (1989, 2863 citations).

  3. #8 ObjectivesPatient-reported outcomes (PROs) are essential when evaluating many new treatments in health care; yet, current measures have been limited by a lack of precision, standardization, and comparability of scores across studies and diseases.

    The Patient-Reported Outcomes Measurement Information System (PROMIS… (2010)

    Extracted from indexed expert opinion literature (2010, 4192 citations).

  4. #9 Though biofilms were first described by Antonie van Leeuwenhoek, the theory describing the biofilm process was not developed until 1978.

    Biofilms: survival mechanisms of clinically relevant microorganisms. (2002)

    Extracted from indexed expert opinion literature (2002, 3875 citations).

  5. #10 Electrocatalysis plays a central role in clean energy conversion, enabling a number of sustainable processes for future technologies.

    Combining theory and experiment in electrocatalysis: Insights into m… (2017)

    Extracted from indexed expert opinion literature (2017, 3707 citations).

  6. #11 The capacity to exercise control over the nature and quality of one's life is the essence of humanness.

    Social cognitive theory: an agentic perspective. (2001)

    Extracted from indexed expert opinion literature (2001, 3431 citations).

  7. #12 BackgroundModern medicine often clashes with traditional medicine such as Chinese herbal medicine because of the little understanding of the underlying mechanisms of action of the herbs.

    TCMSP: a database of systems pharmacology for drug discovery from he… (2014)

    Extracted from indexed expert opinion literature (2014, 3520 citations).

Where the record disagrees (2 controversies)
  • Topological Data Analysis Signal-to-Noise vs Spurious Cavities: Debate over whether high-dimensional topological cavities detected in noisy financial tick data represent genuine invariant market regime structures or finite-sample geometric noise artifacts.

    Findings #2, #4

  • Systemic Risk Metric Adequacy: Contention over whether static network clearing vectors (Eisenberg-Noe) adequately capture endogenous dynamic fire sales, liquidity hoarding, and collateral run dynamics during crises.

    Findings #3

In the world (5 institutes, experiments, and groups)

Found on the web. Only entries a retrieved page supports are kept; verify before acting.

Companies

NameCountryWhat the sources say
Ayasdi (SymphonyAI)United StatesPioneering enterprise enterprise machine learning company co-founded by Gunnar Carlsson to commercialize topological data analysis (TDA) for financial crime and fraud detection.
technology
Topological Data Analysis, Persistent Homology Software
source

Research groups

NameCountryWhat the sources say
Clay Mathematics InstituteUnited StatesDedicated to increasing and disseminating mathematical knowledge, famous for establishing the seven Millennium Prize Problems in 2000.
initiatives
Millennium Prize Problems (including Poincaré Conjecture, Navier-Stokes, Hodge, P vs NP)
source

People

NameCountryWhat the sources say
Bernhard RiemannGermanyVisionary mathematician who revolutionized differential geometry, complex analysis (Riemann surfaces), and analytic number theory (Riemann hypothesis).
contributions
Riemannian geometry, Riemann zeta function, Riemann surfaces
source
Gunnar CarlssonUnited StatesStanford professor of mathematics who pioneered the mathematical foundations and computational algorithms of Topological Data Analysis.
field
Algebraic topology, persistent homology, applied geometry
institution
Stanford University
source
Jules Henri PoincaréFrancePolymath mathematician, theoretical physicist, and engineer who founded algebraic topology, discovered deterministic chaos in the three-body problem, and contributed to special relativity.
contributions
Analysis Situs, Poincaré Conjecture, Three-Body Chaos, Conventionalism
source

Node lineage & crossover disciplines

Parent lineage, active node, direct child sub-branches, and associated crossover disciplines across the Tree of Knowledge.

+ Associated nodes:

Branches

AI Tree OrganiserExpand Pure & Applied Mathematics, Geometry & Topology

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Primary indexed sources (30)

Primary scientific literature, systematic reviews, and clinical trial registrations indexed for this branch.

  1. Mapping transcriptomic vector fields of single cells. — Qiu X, Zhang Y, Martin-Rufino JD et al. Cell, 2022, expert opinion, 411 citations · DOI: 10.1016/j.cell.2021.12.045
  2. The ORCA quantum chemistry program package. — Neese F, Wennmohs F, Becker U et al. The Journal of chemical physics, 2020, expert opinion, 2547 citations · DOI: 10.1063/5.0004608
  3. Mutations Strengthened SARS-CoV-2 Infectivity. — Chen J, Wang R, Wang M et al. Journal of molecular biology, 2020, expert opinion, 390 citations · DOI: 10.1016/j.jmb.2020.07.009
  4. A topology-based network tree for the prediction of protein-protein binding affinity changes following mutation. — Wang M, Cang Z, Wei GW Nature machine intelligence, 2020, expert opinion, 172 citations · DOI: 10.1038/s42256-020-0149-6
  5. Graph theory methods: applications in brain networks. — Sporns O Dialogues in clinical neuroscience, 2018, expert opinion, 424 citations · DOI: 10.31887/dcns.2018.20.2/osporns
  6. Representability of algebraic topology for biomolecules in machine learning based scoring and virtual screening. — Cang Z, Mu L, Wei GW PLoS computational biology, 2018, expert opinion, 186 citations · DOI: 10.1371/journal.pcbi.1005929
  7. Cliques and cavities in the human connectome. — Sizemore AE, Giusti C, Kahn A et al. Journal of computational neuroscience, 2018, expert opinion, 164 citations · DOI: 10.1007/s10827-017-0672-6
  8. Combining theory and experiment in electrocatalysis: Insights into materials design. — Seh ZW, Kibsgaard J, Dickens CF et al. Science (New York, N.Y.), 2017, expert opinion, 3707 citations · DOI: 10.1126/science.aad4998
  9. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells. — Taguchi A, Nishinakamura R Cell stem cell, 2017, in vitro, 344 citations · DOI: 10.1016/j.stem.2017.10.011
  10. Two's company, three (or more) is a simplex : Algebraic-topological tools for understanding higher-order structure in neural data. — Giusti C, Ghrist R, Bassett DS Journal of computational neuroscience, 2016, animal, 193 citations · DOI: 10.1007/s10827-016-0608-6
  11. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. — Ru J, Li P, Wang J et al. Journal of cheminformatics, 2014, expert opinion, 3520 citations · DOI: 10.1186/1758-2946-6-13
  12. Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility. — Jain N, Iyer KV, Kumar A et al. Proceedings of the National Academy of Sciences of the United States of America, 2013, expert opinion, 305 citations · DOI: 10.1073/pnas.1300801110
  13. The retinotopic organization of striate cortex is well predicted by surface topology. — Benson NC, Butt OH, Datta R et al. Current biology : CB, 2012, expert opinion, 227 citations · DOI: 10.1016/j.cub.2012.09.014
  14. On the growth and form of the gut. — Savin T, Kurpios NA, Shyer AE et al. Nature, 2011, expert opinion, 381 citations · DOI: 10.1038/nature10277
  15. The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005-2008. — Cella D, Riley W, Stone A et al. Journal of clinical epidemiology, 2010, expert opinion, 4192 citations · DOI: 10.1016/j.jclinepi.2010.04.011
  16. Topology and Data — Gunnar Carlsson Bulletin of the American Mathematical Society, 2009, computational, 3950 citations · DOI: 10.1090/s0273-0979-09-01249-x
  17. Continuous particle separation in spiral microchannels using Dean flows and differential migration. — Bhagat AA, Kuntaegowdanahalli SS, Papautsky I Lab on a chip, 2008, expert opinion, 322 citations · DOI: 10.1039/b807107a
  18. Neural probe design for reduced tissue encapsulation in CNS. — Seymour JP, Kipke DR Biomaterials, 2007, expert opinion, 315 citations · DOI: 10.1016/j.biomaterials.2007.03.024
  19. Biofilms: survival mechanisms of clinically relevant microorganisms. — Donlan RM, Costerton JW Clinical microbiology reviews, 2002, expert opinion, 3875 citations · DOI: 10.1128/cmr.15.2.167-193.2002
  20. Synchronization in small-world systems. — Barahona M, Pecora LM Physical review letters, 2002, expert opinion, 481 citations · DOI: 10.1103/physrevlett.89.054101
  21. Social cognitive theory: an agentic perspective. — Bandura A Annual review of psychology, 2001, expert opinion, 3431 citations · DOI: 10.1146/annurev.psych.52.1.1
  22. Systemic Risk in Financial Systems — Larry Eisenberg, Thomas H. Noe Management Science, 2001, cohort, 2850 citations · DOI: 10.1287/mnsc.47.2.236.9835
  23. From social integration to health: Durkheim in the new millennium. — Berkman LF, Glass T, Brissette I et al. Social science & medicine (1982), 2000, expert opinion, 2472 citations · DOI: 10.1016/s0277-9536(00)00065-4
  24. EEG and MEG: forward solutions for inverse methods. — Mosher JC, Leahy RM, Lewis PS IEEE transactions on bio-medical engineering, 1999, expert opinion, 470 citations · DOI: 10.1109/10.748978
  25. Salient features of synaptic organisation in the cerebral cortex. — Somogyi P, Tamás G, Lujan R et al. Brain research. Brain research reviews, 1998, expert opinion, 678 citations · DOI: 10.1016/s0165-0173(97)00061-1
  26. Modular Elliptic Curves and Fermat's Last Theorem — Andrew Wiles Annals of Mathematics, 1995, computational, 4900 citations · DOI: 10.2307/2118559
  27. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. — Lander ES, Botstein D Genetics, 1989, expert opinion, 2863 citations · DOI: 10.1093/genetics/121.1.185
  28. Supersymmetry and Morse Theory — Edward Witten Journal of Differential Geometry, 1982, systematic review, 3100 citations · DOI: 10.4310/jdg/1214437492
  29. Analysis Situs — Henri Poincaré Journal de l'École Polytechnique, 1895, systematic review, 4300 citations · DOI: 10.1017/cbo9780511701344.002
  30. Ueber die Hypothesen, welche der Geometrie zu Grunde liegen — Bernhard Riemann Abhandlungen der Königlichen Gesellschaft der Wissenschaften zu Göttingen, 1868, systematic review, 5120 citations · DOI: 10.1007/978-3-642-35121-1_1