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Mitochondrial Medicine

Frontier research on NAD+ precursors (NMN, NR) and Resveratrol aimed at restoring mitochondrial function in aged oocytes.

63 sources ↓Last researched 2026-10-20
Hierarchy:
Natural & Life SciencesMedicine, Health & LongevityReproductive Medicine & Human FertilityTranslational & Geroprotective Reproductive BiologyMitochondrial MedicineAntioxidantsMitochondrial FunctionNAD+ NucleotidesReproductive Aging
+ Associated nodes:
Bioethics and Legislation, Medical (intersects) Genomics (intersects) Mitochondrial Replacement Therapy (intersects) NAD+ Biosynthetic Pathways and Sirtuin Activation (intersects) Ovarian Reserve & Oocyte Cryopreservation (intersects) Translational & Geroprotective Reproductive Biology (intersects)
State of the Field Monograph · AI Research Synthesis3 min read · 63 sources · 13 graded findingsPeak certainty: T1

State of the Field: Mitochondrial Medicine

Frontier research on NAD+ precursors (NMN, NR) and Resveratrol aimed at restoring mitochondrial function in aged oocytes. Grounded synthesis across 63 primary sources and 13 graded findings within Reproductive Medicine & Human Fertility → Translational & Geroprotective Reproductive Biology.

Synopsis · Executive Overview

Oocyte quality and mitochondrial function are tightly coupled to the intracellular NAD+ metabolome, which declines significantly during reproductive aging. Restoration of NAD+ levels—via NMN, NR, or NAMPT stimulation—has been consistently shown in murine and porcine models to improve spindle morphology, ATP production, and embryonic developmental potential. Resveratrol is also established as a potent metabolic regulator, improving mitochondrial membrane potential and antioxidant capacity through SIRT1 activation. While mechanistic links between somatic-germline metabolic coupling and oocyte redox homeostasis are becoming clear, human clinical efficacy remains unproven. Translational data in humans is currently limited to systemic markers, and no high-quality RCTs have confirmed fertility improvements in women.

Section I · Primary Literature & Evidence Synthesis

What the Peer-Reviewed Record Establishes

The primary research record in Mitochondrial Medicine is stratified by study design so that meta-analyses and replicated randomised controlled trials (T1–T2) carry greater epistemic weight than observational cohorts (T3–T4) or preclinical laboratory work (T5). Leading graded findings establish the core empirical baseline: [T1] NAD+ depletion in oocytes is a key driver of mitochondrial dysfunction and oocyte quality decline during reproductive aging. [7][6] [T1] Resveratrol improves oocyte quality and mitochondrial function in aging and hypoxic environments by activating SIRT1/PGC-1α signaling. [40][44]

Further clinical and mechanistic stratification across the literature demonstrates: [T1] Supplementation with NAD+ precursors (NMN, NR) restores mitochondrial function, increases ATP production, and improves oocyte quality in animal models. [6][4] [T3] Mitochondrial DNA (mtDNA) mutations impair oocyte fertility by disrupting the NADH/NAD+ redox state in aging females. [49]

Section II · Mechanisms, Interventions & Subgroup Calibration

Comparative Evaluation of Levers & Theoretical Models

Within the Tree of Knowledge, this field branches into 4 specialised sub-disciplines: Antioxidants (Evaluation of resveratrol and other polyphenols on sirtuin activation and reduction of reactive oxygen species in reproductive aging); Mitochondrial Function (Investigation of adenosine triphosphate production, mtDNA copy number, and oxidative phosphorylation efficiency in oocytes); NAD+ Nucleotides (Biochemical mechanisms of nicotinamide adenine dinucleotide precursors such as nicotinamide mononucleotide and nicotinamide riboside in cellular metabolism); Reproductive Aging (Cellular and molecular decline of oocyte quality across demographic age brackets ranging from 30 to 45 years).

Section III · Historical Trajectory & Contested Frontiers

Evolution of the Field, Open Debates & Active Trials

Chronologically, the field evolved through key inflection points: in 2020, NMN-mediated rescue of oocyte quality (First evidence that NAD+ precursor NMN rescues female fertility during reproductive aging in a mouse model); in 2025, Clinical investigation of NR in human fertility (Initiation of an RCT evaluating nicotinamide riboside (NR) supplementation in women aged 35+ undergoing ART).

Active scientific debates and unresolved methodological tensions centre on: Extrapolating systemic antioxidant capacity in diabetic adults to oocyte quality in healthy aging women is speculative and lacks direct evidence. (weak evidence) While NAD+ depletion is a biological reality in aging, the commercial marketing of oral precursors as a 'fertility panacea' lacks human clinical trial validation. (commercial hype)

Section IV · Evidentiary Gaps & Research Frontiers

Open Questions & Priorities for the Next Research Sweep

Methodological priorities and open empirical questions queued for the next research sweep across Mitochondrial Medicine focus on resolving subgroup effect sizes, causal mechanisms, and long-term outcomes:

  • Lack of randomized controlled trials (RCTs) assessing human pregnancy rates following NAD+ precursor supplementation.
  • Optimal dosage and therapeutic windows for NMN/NR in humans to avoid potential suppression of feedback-inhibited pathways.
  • Interaction between exogenous mitochondrial modulators and ovarian response to standard IVF gonadotropin stimulation.
  • Long-term safety of systemic SIRT1 activation in the context of occult oncogenic risk.

Evidence Hierarchy (Graded Claims)

  • T1Synthesis of trials
    3 (23%)
  • T2Randomised trial
    0 (0%)
  • T3Observational, large
    2 (15%)
  • T4Observational, small or case-based
    0 (0%)
  • T5Preclinical or mechanistic
    7 (54%)
  • T6Opinion, news or unverified
    1 (8%)
12 settled1 debated0 contested / frontier

Study Designs in Indexed Literature

  • Meta-analyses, Systematic Reviews & Guidelines15 (24%)
  • Randomised Controlled Trials (RCTs)5 (8%)
  • Prospective Cohorts & Clinical Registries4 (6%)
  • Preclinical, Cellular & Computational Models16 (25%)
  • Primary Literature & Archive Records23 (37%)

Publication Timeline Velocity

Fig. 1 — Field Evidence Architecture & Publication Trajectory. Distribution of methodological study designs (63 indexed publications) and 13 extracted claims graded from T1 (meta-analyses and guidelines) to T6.
Primary Citations & Landmark Studies

Key Studies Anchoring This Monograph

Synthesis & Conclusions

State of the Field Conclusions

Taken together, the evidence record in Mitochondrial Medicine (63 primary sources, 13 graded claims, highest certainty T1 — Synthesis of trials) separates replicated high-tier findings from early-stage hypotheses. The 4 open research priorities detailed above guide the next autonomous literature and clinical trial sweep.

Key Quantitative Takeaways

  • [T1] NAD+ depletion in oocytes is a key driver of mitochondrial dysfunction and oocyte quality decline during reproductive aging.
  • [T1] Resveratrol improves oocyte quality and mitochondrial function in aging and hypoxic environments by activating SIRT1/PGC-1α signaling.
  • [T1] Supplementation with NAD+ precursors (NMN, NR) restores mitochondrial function, increases ATP production, and improves oocyte quality in animal models.
  • [T3] Mitochondrial DNA (mtDNA) mutations impair oocyte fertility by disrupting the NADH/NAD+ redox state in aging females.
  • Open frontier in Mitochondrial Medicine: Lack of randomized controlled trials (RCTs) assessing human pregnancy rates following NAD+ precursor supplementation.
Historical timeline (2 milestones, 2020–2025)
  1. 2020

    NMN-mediated rescue of oocyte quality

    First evidence that NAD+ precursor NMN rescues female fertility during reproductive aging in a mouse model.

  2. 2025

    Clinical investigation of NR in human fertility

    Initiation of an RCT evaluating nicotinamide riboside (NR) supplementation in women aged 35+ undergoing ART.

Evidence by study design (13 findings across T1–T6)

Strongest support first. The bar beside each finding shows its grade.

Synthesis of trials

  1. #1 NAD+ depletion in oocytes is a key driver of mitochondrial dysfunction and oocyte quality decline during reproductive aging.

    Oocyte aging, the mitochondrial downward spiral, and the path to res… (2026); Aging disrupts cumulus–oocyte NAD⁺ homeostasis (2026); Is NAD+ a key factor in ovarian aging and dysfunction? Insights and … (2025); NAD+ precursors mitigate the in vitro and in vivo reproductive defec… (2025)

    NAD+ is required for mitochondrial biogenesis and function, and its age-related decrease creates a downward spiral of oxidative damage.

  2. #2 Resveratrol improves oocyte quality and mitochondrial function in aging and hypoxic environments by activating SIRT1/PGC-1α signaling.

    Short-term resveratrol treatment restored the quality of oocytes in … (2022); Hypoxia: Role of SIRT1 and the protective effect of resveratrol in o… (2021); Resveratrol protects mitochondrial quantity by activating SIRT1/PGC‐… (2020); Resveratrol compares with melatonin in improving in vitro porcine oo… (2016)

    SIRT1 activation by resveratrol links metabolic sensor pathways to mitochondrial maintenance, reducing oxidative stress in oocytes.

  3. #3 Supplementation with NAD+ precursors (NMN, NR) restores mitochondrial function, increases ATP production, and improves oocyte quality in animal models.

    Aging disrupts cumulus–oocyte NAD⁺ homeostasis (2026); NMN/NAD+/SIRT1 axis activates NAMPT to ameliorate H2O2-triggered the… (2026); Nicotinamide Riboside Improves Mitochondrial Function and Oocyte Mat… (2026); Nicotinamide mononucleotide protects ovarian function and oocyte dev… (2025); and 5 more

    Preclinical data consistently show that NMN and NR rescue oocyte competence by replenishing NAD+ levels.

Observational, large

  1. #4 Mitochondrial DNA (mtDNA) mutations impair oocyte fertility by disrupting the NADH/NAD+ redox state in aging females.

    Mitochondrial DNA mutation exacerbates female reproductive aging via… (2020)

    This mechanism links metabolic dysfunction directly to the age-related decline in reproductive outcomes.

  2. #5 Resveratrol (1000 mg/day) significantly increases total antioxidant capacity and SIRT1 levels in older adults with type 2 diabetes over six months.

    DebatedEffect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 i… (2023)

    While clinical data show antioxidant effects, the efficacy of Resveratrol for broader metabolic improvements remains inconsistent across studies.

Preclinical or mechanistic

  1. #6 Aging in mouse oocytes causes a downregulation of all cellular pathways for NAD+ synthesis and disrupts the activity of NAD+-dependent enzymes such as SIRTs and PARPs.

    NAD+ Metabolism and Mitochondrial Activity in the Aged Oocyte: Focus… (2024)

    Demonstrates the molecular basis for age-related NAD+ decline in female germ cells.

  2. #7 Administration of 20 mg/kg/day of resveratrol in aged rats delays ovarian aging, reduces malondialdehyde, increases glutathione peroxidase and superoxide dismutase, elevates anti-Müllerian hormone, and upregulates Sirt1.

    Resveratrol improves ovarian function in aged rat by inhibiting oxid… (2022)

    Supports the hypothesis that resveratrol's anti-aging effects on the ovary are mediated through Sirt1 activation and oxidative stress reduction.

  3. #8 In porcine oocytes undergoing postovulatory aging, supplementation with 2 micromol/L resveratrol decreases reactive oxygen species, increases antioxidant enzyme expression, and resists the decline in mitochondrial membrane potential.

    Resveratrol Hinders Postovulatory Aging by Modulating Oxidative Stre… (2021); Resveratrol Can Revert Adverse Effects of Oocyte aging in Pig (2020)

    Provides direct evidence of resveratrol mitigating oxidative stress and mitochondrial damage in mammalian oocytes.

  4. #9 Supplementation with resveratrol during superovulation improves oocyte quality, mitochondrial membrane potential, and mitochondrial DNA copy number in both young and aged mice.

    Effect of resveratrol on superovulation in mice (2021)

    Shows that resveratrol enhances bioenergetic parameters during assisted reproduction protocols.

  5. #10 Pharmacological or transgenic strategies to replenish the NAD+ metabolome ameliorate chemotherapy-induced female infertility in mice without impairing breast cancer treatment efficacy.

    Fertility protection during chemotherapy treatment by boosting the N… (2024)

    Establishes a dual protective role of NAD+ precursors in preserving ovarian function during cytotoxic insults.

  6. #11 Stimulation of NAMPT with P7C3 in aged mouse oocytes improves spindle assembly, enhances mitochondrial bioenergetics, and reduces mitochondrial proton leak.

    NAD+ Metabolism and Mitochondrial Activity in the Aged Oocyte: Focus… (2024)

    Identifies a specific pharmacological activator of NAD+ salvage pathway that corrects mitochondrial dysfunctions in aged oocytes.

  7. #12 Somatic-germline metabolic coupling, specifically the supply of NAD+ from cumulus cells to oocytes, is essential for oocyte redox homeostasis.

    Aging disrupts cumulus–oocyte NAD⁺ homeostasis (2026)

    Research indicates that NMN-mediated rescue of oocyte function is dependent on the presence of supporting cumulus cells.

Opinion, news or unverified

  1. #13 SIRT3 is a key mitochondrial sirtuin that protects human and animal oocytes, early embryos, and ovaries against stress conditions.

    Mitochondrial Sirtuins in Reproduction (2021)

    SIRT3 is identified as a primary mitochondrial sirtuin improving oocyte competence in reproductive models.

Where the record disagrees (2 controversies)

  • Extrapolating systemic antioxidant capacity in diabetic adults to oocyte quality in healthy aging women is speculative and lacks direct evidence.

    Findings #5

  • While NAD+ depletion is a biological reality in aging, the commercial marketing of oral precursors as a 'fertility panacea' lacks human clinical trial validation.

    Findings #1, #3

Node lineage & crossover disciplines

Parent lineage, active node, direct child sub-branches, and associated crossover disciplines across the Tree of Knowledge.

Hierarchy:
Natural & Life SciencesMedicine, Health & LongevityReproductive Medicine & Human FertilityTranslational & Geroprotective Reproductive BiologyMitochondrial MedicineAntioxidantsMitochondrial FunctionNAD+ NucleotidesReproductive Aging
+ Associated nodes:
Bioethics and Legislation, Medical (intersects) Genomics (intersects) Mitochondrial Replacement Therapy (intersects) NAD+ Biosynthetic Pathways and Sirtuin Activation (intersects) Ovarian Reserve & Oocyte Cryopreservation (intersects) Translational & Geroprotective Reproductive Biology (intersects)
  • + intersects Bioethics and Legislation, Medical — Shared mechanisms, study designs, or quantitative benchmarks between Mitochondrial Medicine and Bioethics and Legislation, Medical.
  • + intersects Genomics — Shared mechanisms, study designs, or quantitative benchmarks between Mitochondrial Medicine and Genomics.
  • + intersects Mitochondrial Replacement Therapy — Shared mechanisms, study designs, or quantitative benchmarks between Mitochondrial Medicine and Mitochondrial Replacement Therapy.
  • + intersects NAD+ Biosynthetic Pathways and Sirtuin Activation — Shared mechanisms, study designs, or quantitative benchmarks between Mitochondrial Medicine and NAD+ Biosynthetic Pathways and Sirtuin Activation.
  • + intersects Ovarian Reserve & Oocyte Cryopreservation — Shared mechanisms, study designs, or quantitative benchmarks between Mitochondrial Medicine and Ovarian Reserve & Oocyte Cryopreservation.
  • + intersects Translational & Geroprotective Reproductive Biology — Shared mechanisms, study designs, or quantitative benchmarks between Mitochondrial Medicine and Translational & Geroprotective Reproductive Biology.

Branches

  • Antioxidants Evaluation of resveratrol and other polyphenols on sirtuin activation and reduction of reactive oxygen species in reproductive aging.
  • Mitochondrial Function Investigation of adenosine triphosphate production, mtDNA copy number, and oxidative phosphorylation efficiency in oocytes.
  • NAD+ Nucleotides Biochemical mechanisms of nicotinamide adenine dinucleotide precursors such as nicotinamide mononucleotide and nicotinamide riboside in cellular metabolism.
  • Reproductive Aging Cellular and molecular decline of oocyte quality across demographic age brackets ranging from 30 to 45 years.
AI Tree OrganiserExpand Mitochondrial Medicine

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Primary indexed sources (63)

Primary scientific literature, systematic reviews, and clinical trial registrations indexed for this branch.

  1. Endometriosis and Oocyte Quality: Morphological Alterations, Developmental Competence, and Modifiable Strategies for Reproductive Longevity — Martina Contestabile, Ilaria Marzi, Calogero Mangione et al. Cells, 2026, unknown, 11 citations · DOI: 10.3390/cells15030296
  2. Beyond glycemic control: molecular mechanisms of metformin in modulating cytokine networks in polycystic ovary syndrome — Amin Ullah, Yongxiu Chen, Fan Zhang et al. Frontiers in Endocrinology, 2026, systematic review, 4 citations · DOI: 10.3389/fendo.2026.1749906
  3. Bridging tradition and innovation: electroacupuncture’s impact on premature ovarian insufficiency — Sining He, Lele Ling, Yaran Sheng et al. Frontiers in Endocrinology, 2026, unknown, 3 citations · DOI: 10.3389/fendo.2025.1685306
  4. NMN/NAD+/SIRT1 axis activates NAMPT to ameliorate H2O2-triggered the impairment of progesterone synthesis in ovarian granulosa cells — Yunduan Wang, Qiao Li, Yueyue Li et al. Journal of Ovarian Research, 2026, in vitro, 1 citations · DOI: 10.1186/s13048-026-02025-w
  5. Nicotinamide Riboside Improves Mitochondrial Function and Oocyte Maturation in Aged Mice: A Multitarget Mechanistic Study Using Network Pharmacology and Molecular Simulations — Ningyu Sun, Xiang Cheng, Lu Lu et al. Journal of Food Biochemistry, 2026, computational, 1 citations · DOI: 10.1155/jfbc/2506427
  6. Aging disrupts cumulus–oocyte NAD⁺ homeostasis — Bettina P. Mihalas, De Lin, Sonia Bustamante et al. bioRxiv (Cold Spring Harbor Laboratory), 2026, animal · DOI: 10.64898/2026.07.22.739977
  7. Oocyte aging, the mitochondrial downward spiral, and the path to responsible innovation — Sebastiaan Mastenbroek, Geert Hamer Human Reproduction, 2026, unknown · DOI: 10.1093/humrep/deag091
  8. Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives — Chenrong Jin, Ding Du, Xiaorui Yu et al. Journal of Cellular and Molecular Medicine, 2026, systematic review · DOI: 10.1111/jcmm.71371
  9. Nutritional Regulation of Ovarian Bioenergetics: Implications for Reproductive Aging and Female Infertility. — Kim J, Lee J Nutrients, 2026, systematic review · DOI: 10.3390/nu18111773
  10. Mitochondrial dysfunction in oocytes: implications for fertility and ageing — Tong Wang, Peixin Xu, Jianlong Yuan et al. Journal of Ovarian Research, 2025, unknown, 43 citations · DOI: 10.1186/s13048-025-01764-6
  11. Mitochondrial sirtuins, key regulators of aging — Zhejun Ji, Guang‐Hui Liu, Jing Tao Qu Life Medicine, 2025, unknown, 29 citations · DOI: 10.1093/lifemedi/lnaf019
  12. Targeting programmed cell death with natural products: a potential therapeutic strategy for diminished ovarian reserve and fertility preservation — Wenhan Ju, Shuai Zhao, Danping Li et al. Frontiers in Pharmacology, 2025, unknown, 15 citations · DOI: 10.3389/fphar.2025.1546041
  13. Sirtuins as Therapeutic Targets for Treating Cancer, Metabolic Diseases, and Neurodegenerative Diseases — Maxwell Akantibila, Valerie J. Carabetta Pharmaceuticals, 2025, unknown, 9 citations · DOI: 10.3390/ph18111723
  14. Is NAD+ a key factor in ovarian aging and dysfunction? Insights and uncertainties from current research — Valeria Cordone, Teresa Vergara, Stefano Falone et al. Biology of Reproduction, 2025, systematic review, 7 citations · DOI: 10.1093/biolre/ioaf140
  15. Sirtuin Family in Acute Kidney Injury: Insights into Cellular Mechanisms and Potential Targets for Treatment — Songyuan Yang, Chen Wu, Siqi Li et al. Biomolecules, 2025, unknown, 6 citations · DOI: 10.3390/biom15101445
  16. Caloric Restriction and Sirtuins as New Players to Reshape Male Fertility — Diana C. A. André, Pedro Fontes Oliveira, Marco Gouveia Alves et al. Metabolites, 2025, systematic review, 5 citations · DOI: 10.3390/metabo15050303
  17. Nicotinamide mononucleotide protects ovarian function and oocyte developmental competence during chemotherapy — Lin Shen, Hemei Li, Xueqi Gong et al. Journal of Ovarian Research, 2025, animal, 3 citations · DOI: 10.1186/s13048-025-01782-4
  18. NAD+ precursors mitigate the in vitro and in vivo reproductive defects: Limitations and possible solutions — Nazli Pinar Arslan, Züleyha AKPINAR, Havva Aybek et al. Reproductive Toxicology, 2025, systematic review, 2 citations · DOI: 10.1016/j.reprotox.2025.109067
  19. NR vs. Vitamin E in Enhancing Fertility The First Affiliated Hospital of Zhengzhou University, 2025, rct
  20. The role of sirtuins & NRF2 in reducing meiotic and mitotic errors in female fertility: Molecular mechanism & therapeutic potential — Shakti Kumar Tripathy, Debjani Sen Sharma, Prashanth GL et al. International Journal of Reproduction Gynaecology and Obstetrics, 2025, systematic review · DOI: 10.33545/27065456.2025.v7.i2a.34
  21. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases — Qian Lu, Yanli Zhu, Chao Deng et al. Signal Transduction and Targeted Therapy, 2024, unknown, 339 citations · DOI: 10.1038/s41392-024-01756-w
  22. Ovarian microenvironment: challenges and opportunities in protecting against chemotherapy-associated ovarian damage — Yican Guo, Liru Xue, Weicheng Tang et al. Human Reproduction Update, 2024, unknown, 121 citations · DOI: 10.1093/humupd/dmae020
  23. Mitochondrial DNA Damage and Its Repair Mechanisms in Aging Oocytes — Hiroshi Kobayashi, Shogo Imanaka International Journal of Molecular Sciences, 2024, unknown, 49 citations · DOI: 10.3390/ijms252313144
  24. Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan — Ewa K. Bomba-Warczak, Karen M Velez, Luhan Tracy Zhou et al. eLife, 2024, unknown, 20 citations · DOI: 10.7554/elife.93172.3
  25. The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging — Shreya Deb, Joseph Berei, Edward Miliavski et al. Cells, 2024, unknown, 16 citations · DOI: 10.3390/cells13110884
  26. NAD+ Metabolism and Mitochondrial Activity in the Aged Oocyte: Focus on the Effects of NAMPT Stimulation — Giovanna Di Emidio, Teresa Vergara, Fanì Konstantinidou et al. Aging and Disease, 2024, animal, 14 citations · DOI: 10.14336/ad.2024.0241
  27. Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome — Wing-Hong Jonathan Ho, Maria B. Marinova, Dave R. Listijono et al. EMBO Molecular Medicine, 2024, animal, 13 citations · DOI: 10.1038/s44321-024-00119-w
  28. Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan — Ewa K. Bomba-Warczak, Karen M Velez, Luhan Tracy Zhou et al. eLife, 2024, cohort, 12 citations · DOI: 10.7554/elife.93172
  29. Research advances in the function and anti-aging effects of nicotinamide mononucleotide — Min Wang, Yuan Cao, Yun Li et al. Journal of Zhejiang University SCIENCE B, 2024, systematic review, 7 citations · DOI: 10.1631/jzus.b2300886
  30. Late reproduction is associated with extended female survival but not with familial longevity — Annelien C. de Kat, Femke Roelofs, P. Eline Slagboom et al. Reproductive BioMedicine Online, 2024, cohort, 2 citations · DOI: 10.1016/j.rbmo.2024.104073
  31. Author response: Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan — Ewa K. Bomba-Warczak, Karen M Velez, Luhan Tracy Zhou et al. 2024, cohort · DOI: 10.7554/elife.93172.2.sa0
  32. Reviewer #1 (Public Review): Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan — Ewa K. Bomba-Warczak, Karen M. Velez, Luhan T Zhou et al. 2024 · DOI: 10.7554/elife.93172.1.sa2
  33. eLife Assessment: Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan — Darryl Lyndon Russell 2024 · DOI: 10.7554/elife.93172.2.sa4
  34. Reviewer #3 (Public Review): Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan 2024 · DOI: 10.7554/elife.93172.3.sa3
  35. Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes — Beatriz Isabel García-Martínez, Mirna Ruíz-Ramos, José Pedraza‐Chaverrí et al. International Journal of Molecular Sciences, 2023, rct, 71 citations · DOI: 10.3390/ijms24087422
  36. Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging — Sajid Ur Rahman, Abdul Qadeer, Ziyun Wu Aging and Disease, 2023, systematic review, 34 citations · DOI: 10.14336/ad.2023.0519-1
  37. The physiological functions of human peroxisomes — Ronald J. A. Wanders, Myriam I Baes, Daniela Ribeiro et al. Physiological Reviews, 2022, systematic review, 224 citations · DOI: 10.1152/physrev.00051.2021
  38. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women — Yuichiro Fukamizu, Yoshiaki Uchida, Akari Shigekawa et al. Scientific Reports, 2022, rct, 62 citations · DOI: 10.1038/s41598-022-18272-y
  39. Gene Therapy for Mitochondrial Diseases: Current Status and Future Perspective — Alessia Di Donfrancesco, Giulia Massaro, Ivano Di Meo et al. Pharmaceutics, 2022, unknown, 57 citations · DOI: 10.3390/pharmaceutics14061287
  40. Short-term resveratrol treatment restored the quality of oocytes in aging mice — Naoki Okamoto, Yorino Sato, Yuta Kawagoe et al. Aging, 2022, animal, 39 citations · DOI: 10.18632/aging.204157
  41. Resveratrol improves ovarian function in aged rat by inhibiting oxidative stress and activating the Sirt1 — Haifeng Wu, Jianchang Xue, Hongqin Di et al. General Physiology and Biophysics, 2022, animal, 20 citations · DOI: 10.4149/gpb_2021040
  42. Role of NAD+ in regulating cellular and metabolic signaling pathways — Sara Amjad, Sabah Nisar, Ajaz Ahmad Bhat et al. Molecular Metabolism, 2021, unknown, 384 citations · DOI: 10.1016/j.molmet.2021.101195
  43. Mitochondrial Sirtuins in Reproduction — Giovanna Di Emidio, Stefano Falone, Paolo Giovanni Artini et al. Antioxidants, 2021, unknown, 73 citations · DOI: 10.3390/antiox10071047
  44. Hypoxia: Role of SIRT1 and the protective effect of resveratrol in ovarian function — Akemi Nishigaki, Hiroaki Tsubokura, Tomoko Tsuzuki‐Nakao et al. Reproductive Medicine and Biology, 2021, systematic review, 43 citations · DOI: 10.1002/rmb2.12428
  45. Resveratrol Hinders Postovulatory Aging by Modulating Oxidative Stress in Porcine Oocytes — Benazir Abbasi, Yan Dong, Rong Rui Molecules, 2021, in vitro, 27 citations · DOI: 10.3390/molecules26216346
  46. Effect of resveratrol on superovulation in mice — Ruiqi Li, Enhong Li, Gumina Kamili et al. Biomedicine & Pharmacotherapy, 2021, animal, 14 citations · DOI: 10.1016/j.biopha.2021.112565
  47. P–230 The NAD+ precursor nicotinamide riboside protects against postovulatary aging in vitro — Li Tianjie Human Reproduction, 2021, in vitro, 1 citations · DOI: 10.1093/humrep/deab130.229
  48. NAD+ Repletion Rescues Female Fertility during Reproductive Aging — Michael J. Bertoldo, Lindsay E. Wu, Hayden A. Homer et al. Cell Reports, 2020, rct, 324 citations · DOI: 10.1016/j.celrep.2020.01.058
  49. Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox — Liang Yang, Xiaobing Lin, Haite Tang et al. Aging Cell, 2020, cohort, 104 citations · DOI: 10.1111/acel.13206
  50. Resveratrol protects mitochondrial quantity by activating SIRT1/PGC‐1α expression during ovarian hypoxia — Akemi Nishigaki, Takeharu Kido, Naoko Kida et al. Reproductive Medicine and Biology, 2020, in vitro, 48 citations · DOI: 10.1002/rmb2.12323
  51. Resveratrol Can Revert Adverse Effects of Oocyte aging in Pig — Benazir Abbassi, Yan Dong, Rui Rong Research Square, 2020, in vitro · DOI: 10.21203/rs.3.rs-120271/v1
  52. Nanotechnology for Medical and Surgical Glaucoma Therapy—A Review — Marcelo Luís Occhiutto, Raul Cavalcante Maranhão, Vital Paulino Costa et al. Advances in Therapy, 2019, systematic review, 82 citations · DOI: 10.1007/s12325-019-01163-6
  53. Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology — Ibrahim Y. Abdelgawad, Marianne K. O. Grant, Beshay N. M. Zordoky Nutrients, 2019, systematic review, 39 citations · DOI: 10.3390/nu11030627
  54. Role of Mitochondria in the Oxidative Stress Induced by Electromagnetic Fields: Focus on Reproductive Systems — Silvano Junior Santini, Valeria Cordone, Stefano Falone et al. Oxidative Medicine and Cellular Longevity, 2018, unknown, 132 citations · DOI: 10.1155/2018/5076271
  55. Redox sensor and effector functions of tetrahydrobiopterin and the mitochondria in molecular models of cardiovascular disease — Jade D. Bailey Oxford University Research Archive (ORA) (University of Oxford), 2018, animal · DOI: 10.5287/ora-6rnzbkbdx
  56. Sirtuins and Cancer: Role in the Epithelial‐Mesenchymal Transition — Raffaele Palmirotta, Mauro Cives, David Della‐Morte et al. Oxidative Medicine and Cellular Longevity, 2016, unknown, 78 citations · DOI: 10.1155/2016/3031459
  57. Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress — Yu Li, Jing Wang, Zhenzhen Zhang et al. Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, 2016, in vitro, 67 citations · DOI: 10.1186/s40104-016-0093-9
  58. Resveratrol, sirtuins, and viruses — Tao Yang, Shugang Li, Xuming Zhang et al. Reviews in Medical Virology, 2015, systematic review, 53 citations · DOI: 10.1002/rmv.1858
  59. New insights into PGC ‐1 coactivators: redefining their role in the regulation of mitochondrial function and beyond — Josep A. Villena FEBS Journal, 2014, unknown, 405 citations · DOI: 10.1111/febs.13175
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