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Clinical Nutrition and Assisted Reproductive Technology Outcomes

Evaluation of pre-conception weight management and dietary interventions on live birth rates during in vitro fertilization cycles for individuals aged 40 and over.

103 sources ↓Last researched 2026-10-20
Hierarchy:
Natural & Life SciencesMedicine, Health & LongevityReproductive Medicine & Human FertilityClinical Nutrition and Assisted Reproductive Technology OutcomesAdiposity and Reproductive OutcomesAntioxidant Supplementation ProtocolsDietary Pattern InterventionsMetabolic Health and Embryo MorphokineticsNutritional Status and Oocyte Quality
+ Associated nodes:
Clinical Efficacy & Obstetric Outcomes (intersects) Developmental Competence of Non-2PN Zygotes (intersects) Ovarian Tissue Cryopreservation and Autotransplantation (intersects) Reproductive Medicine & Human Fertility (intersects)
State of the Field Monograph · AI Research Synthesis4 min read · 103 sources · 10 graded findingsPeak certainty: T1

State of the Field: Clinical Nutrition and Assisted Reproductive Technology Outcomes

Evaluation of pre-conception weight management and dietary interventions on live birth rates during in vitro fertilization cycles for individuals aged 40 and over. Grounded synthesis across 103 primary sources and 10 graded findings within Medicine, Health & Longevity → Reproductive Medicine & Human Fertility.

Synopsis · Executive Overview

The impact of preconception weight and diet on IVF outcomes for individuals aged 40 and over remains a subject of intense investigation with limited high-quality evidence. While maternal obesity is generally associated with decreased live birth rates and increased miscarriage risk, clinical trials consistently show that weight loss interventions prior to IVF do not reliably improve live birth outcomes compared to standard care. Dietary patterns such as the Mediterranean diet are correlated with higher success rates in observational studies, yet heterogeneity prevents definitive clinical guidelines. Pharmacological interventions for weight loss have failed to demonstrate improved live birth success. Recent research has shifted toward antioxidant supplementation, with some single-study data suggesting benefits for women aged 38-45, though these findings require rigorous validation.

Section I · Primary Literature & Evidence Synthesis

What the Peer-Reviewed Record Establishes

The primary research record in Clinical Nutrition and Assisted Reproductive Technology Outcomes is stratified by study design so that meta-analyses and replicated randomised controlled trials (T1–T2) carry greater epistemic weight than observational cohorts (T3–T4) or preclinical laboratory work (T5). Leading graded findings establish the core empirical baseline: [T1] Preconception weight reduction and lifestyle modification prior to in vitro fertilization do not significantly improve clinical pregnancy or live birth rates compared with proceeding directly to treatment. [46][52] [T1] Maternal obesity is associated with a 5-7% reduction in live birth rates for every five-unit increase in BMI and a significant rise in miscarriage rates, particularly in twin pregnancies. [6][23]

Further clinical and mechanistic stratification across the literature demonstrates: [T1] Adherence to Mediterranean, profertility, or Dutch preconception dietary patterns is associated with higher pregnancy and live birth rates in cohort studies, though data are too heterogeneous to support a single clinical recommendation. [47] [T2] Multiple clinical trials (n=82-890) are currently evaluating the impact of pre-conception interventions, including weight management through GLP-1 receptor agonists (e.g., liraglutide, tirzepatide) and anti-inflammatory dietary approaches, on IVF outcomes in women diagnosed with PCOS or endometriosis. [15][32]

Section II · Mechanisms, Interventions & Subgroup Calibration

Comparative Evaluation of Levers & Theoretical Models

Within the Tree of Knowledge, this field branches into 5 specialised sub-disciplines: Adiposity and Reproductive Outcomes (Examination of body mass index (BMI) and visceral adipose tissue impact on controlled ovarian stimulation (COS) response and embryo implantation rates); Antioxidant Supplementation Protocols (Systematic review of coenzyme Q10, vitamin D, and omega-3 fatty acid intake on IVF cycle success metrics in perimenopausal women); Dietary Pattern Interventions (Assessment of Mediterranean and low-glycemic index dietary adherence on IVF clinical pregnancy and live birth rates in patients aged 40-45); Metabolic Health and Embryo Morphokinetics (Evaluation of insulin resistance markers and lipid profiles as predictors for blastocyst development and aneuploidy rates); Nutritional Status and Oocyte Quality (Analysis of how micronutrient deficiencies and glycemic index influence oocyte maturation and mitochondrial function in advanced reproductive age populations).

Section III · Historical Trajectory & Contested Frontiers

Evolution of the Field, Open Debates & Active Trials

Chronologically, the field evolved through key inflection points: in 2025, First Standardized Antioxidant Guidelines (Global Andrology Forum establishes the first evidence-based guidelines for antioxidant use in reproductive health via expert consensus); in 2025, OvoVid Phase 2 Results (A multicentric RCT demonstrates that donor supplementation with a multicomponent micronutrient and probiotic formula improves pregnancy outcomes for recipients using vitrified oocytes).

Active scientific debates and unresolved methodological tensions centre on: While general weight loss/lifestyle interventions fail to improve IVF outcomes, targeted supplementation like melatonin shows promising but preliminary and unreplicated benefits in older cohorts. (contradiction) Marketing of 'oocyte rejuvenation' through supplements often relies on murine model data that has not been confirmed in human clinical trials. (commercial hype) Dietary patterns and behavioral interventions are supported mostly by associative data or small-scale pilot studies. (weak evidence)

Section IV · Evidentiary Gaps & Research Frontiers

Open Questions & Priorities for the Next Research Sweep

Methodological priorities and open empirical questions queued for the next research sweep across Clinical Nutrition and Assisted Reproductive Technology Outcomes focus on resolving subgroup effect sizes, causal mechanisms, and long-term outcomes:

  • Lack of large-scale RCTs specifically isolating the 40+ demographic for dietary interventions.
  • Uncertainty regarding the mechanism of action for melatonin in improving IVF outcomes in older cohorts.
  • Insufficient data on the safety and efficacy of GLP-1 receptor agonists in the immediate preconception window for fertility patients.

Evidence Hierarchy (Graded Claims)

  • T1Synthesis of trials
    3 (30%)
  • T2Randomised trial
    1 (10%)
  • T3Observational, large
    5 (50%)
  • T4Observational, small or case-based
    0 (0%)
  • T5Preclinical or mechanistic
    0 (0%)
  • T6Opinion, news or unverified
    1 (10%)
5 settled4 debated1 contested / frontier

Study Designs in Indexed Literature

  • Meta-analyses, Systematic Reviews & Guidelines8 (8%)
  • Randomised Controlled Trials (RCTs)22 (21%)
  • Prospective Cohorts & Clinical Registries7 (7%)
  • Preclinical, Cellular & Computational Models2 (2%)
  • Primary Literature & Archive Records64 (62%)

Publication Timeline Velocity

Fig. 1 — Field Evidence Architecture & Publication Trajectory. Distribution of methodological study designs (103 indexed publications) and 10 extracted claims graded from T1 (meta-analyses and guidelines) to T6.
Primary Citations & Landmark Studies

Key Studies Anchoring This Monograph

Synthesis & Conclusions

State of the Field Conclusions

Taken together, the evidence record in Clinical Nutrition and Assisted Reproductive Technology Outcomes (103 primary sources, 10 graded claims, highest certainty T1 — Synthesis of trials) separates replicated high-tier findings from early-stage hypotheses. The 3 open research priorities detailed above guide the next autonomous literature and clinical trial sweep.

Key Quantitative Takeaways

  • [T1] Preconception weight reduction and lifestyle modification prior to in vitro fertilization do not significantly improve clinical pregnancy or live birth rates compared with proceeding directly to treatment.
  • [T1] Maternal obesity is associated with a 5-7% reduction in live birth rates for every five-unit increase in BMI and a significant rise in miscarriage rates, particularly in twin pregnancies.
  • [T1] Adherence to Mediterranean, profertility, or Dutch preconception dietary patterns is associated with higher pregnancy and live birth rates in cohort studies, though data are too heterogeneous to support a single clinical recommendation.
  • [T2] Multiple clinical trials (n=82-890) are currently evaluating the impact of pre-conception interventions, including weight management through GLP-1 receptor agonists (e.g., liraglutide, tirzepatide) and anti-inflammatory dietary approaches, on IVF outcomes in women diagnosed with PCOS or endometriosis.
  • Open frontier in Clinical Nutrition and Assisted Reproductive Technology Outcomes: Lack of large-scale RCTs specifically isolating the 40+ demographic for dietary interventions.
Historical timeline (2 milestones, 2025–2025)
  1. 2025

    First Standardized Antioxidant Guidelines

    Global Andrology Forum establishes the first evidence-based guidelines for antioxidant use in reproductive health via expert consensus.

  2. 2025

    OvoVid Phase 2 Results

    A multicentric RCT demonstrates that donor supplementation with a multicomponent micronutrient and probiotic formula improves pregnancy outcomes for recipients using vitrified oocytes.

Evidence by study design (10 findings across T1–T6)

Strongest support first. The bar beside each finding shows its grade.

Synthesis of trials

  1. #1 Preconception weight reduction and lifestyle modification prior to in vitro fertilization do not significantly improve clinical pregnancy or live birth rates compared with proceeding directly to treatment.

    Effects of preconception weight loss after lifestyle intervention on… (2022); Effect of Orlistat on Live Birth Rate in Overweight or Obese Women U… (2021); IVF outcomes in patients with a history of bariatric surgery: a mult… (2020); Weight reduction intervention for obese infertile women prior to IVF… (2017)

    Although weight loss interventions successfully lower maternal weight and increase natural conception rates, trials consistently demonstrate no added live birth benefit preceding assisted reproductive technology cycles.

  2. #2 Maternal obesity is associated with a 5-7% reduction in live birth rates for every five-unit increase in BMI and a significant rise in miscarriage rates, particularly in twin pregnancies.

    Modification effect of multiple gestation on the relationship betwee… (2026); Impact of Obesity on In Vitro Fertilization (IVF) Outcomes: A System… (2025)

    While systematic reviews consistently link high BMI to poor outcomes, some large cohorts show a stronger link to miscarriage than to final live birth rates.

  3. #3 Adherence to Mediterranean, profertility, or Dutch preconception dietary patterns is associated with higher pregnancy and live birth rates in cohort studies, though data are too heterogeneous to support a single clinical recommendation.

    DebatedFemale dietary patterns and outcomes of in vitro fertilization (IVF)… (2022)

    Methodological challenges and misclassification of exposure in dietary studies make proving causation difficult.

Randomised trial

  1. #4 Multiple clinical trials (n=82-890) are currently evaluating the impact of pre-conception interventions, including weight management through GLP-1 receptor agonists (e.g., liraglutide, tirzepatide) and anti-inflammatory dietary approaches, on IVF outcomes in women diagnosed with PCOS or endometriosis.

    DebatedMyo-Inositol Alone Versus Myo-Inositol Plus Alpha-Lactalbumin in Wom… (2026); A Clincial Study Testing Tirzepatide on Reproductive Function and Me… (2025); Liraglutide Treatment in Obese Infertile PCOS Women (2025); Dietary Intervention to Improve Fertility in Women With Endometriosi… (2025)

    Evidence is actively being generated; while mechanistic plausibility for weight loss improving fertility is high, clinical proof of live birth rate improvement via these specific pharmacological interventions remains the subject of ongoing RCTs.

Observational, large

  1. #5 Elevated maternal body mass index significantly increases the risk of live birth failure during assisted reproductive technology using autologous oocytes, but this negative impact is stronger in women under age 35 than in older women.

    Female obesity adversely affects assisted reproductive technology (A… (2010)

    Demonstrating that the relative adverse impact of obesity on live births diminishes in older cohorts informs whether delaying in vitro fertilization for weight reduction is clinically sensible given age-related fertility decline.

  2. #6 In women aged 20-40 experiencing early fertility decline, a comprehensive health program including dietary optimization and nutritional supplementation is being evaluated in a multicenter RCT (n=384) to determine if it can improve ovarian reserve scores.

    Early Prevention and Precision Management of Female Fertility Decline (2026)

    This addresses the specific user interest in pre-conception management in women approaching the 40-year threshold.

  3. #7 Interventions such as gamified lifestyle training and mindfulness-based programs in women aged 20-40 undergoing IVF are under investigation (n=92-105) to assess their role in improving IVF treatment outcomes and patient self-efficacy.

    DebatedGamified Healthy Lifestyle Training in Women Undergoing Assisted Rep… (2026); The Effect of Mindfulness-Based Lifestyle Support Program on Inferti… (2025)

    The impact of psychosocial and lifestyle modifications on objective clinical IVF pregnancy rates remains an active area of clinical inquiry.

  4. #8 In women with low-grade systemic inflammation (hsCRP ≥ 1.95 mg/L) and prior pregnancy loss, preconception low-dose aspirin significantly increases live birth rates from 44% to 59%.

    Preconception Low-Dose Aspirin Restores Diminished Pregnancy and Liv… (2017)

    Stratified analysis identifies a specific clinical subgroup where anti-inflammatory intervention directly impacts birth outcomes.

  5. #9 Daily oral supplementation with 2 mg of melatonin for at least eight weeks significantly increased live birth rates from 15.3% to 33.3% in women aged 38 to 45 undergoing in vitro fertilization with frozen embryo transfer.

    DebatedMelatonin supplementation attenuates cuproptosis and ferroptosis in … (2024)

    Melatonin is investigated as a clinical nutritional adjuvant to attenuate oxidative stress and regulated cell death pathways in aging cumulus cells, though broader trial validation remains needed.

Opinion, news or unverified

  1. #10 Coenzyme Q10 and melatonin supplementation show efficacy in restoring mitochondrial activity and reducing chromosomal abnormalities in aged mouse models, but human clinical evidence for improved live birth rates remains inconclusive.

    ContestedOocyte and dietary supplements: a mini review (2025); Effects of Supplementation with Natural Antioxidants on Oocytes and … (2020)

    Preclinical data on age-related reproductive decline is robust, but translation to high-quality human RCTs has not yet occurred.

Where the record disagrees (4 controversies)

  • While general weight loss/lifestyle interventions fail to improve IVF outcomes, targeted supplementation like melatonin shows promising but preliminary and unreplicated benefits in older cohorts.

    Findings #1, #9

  • Marketing of 'oocyte rejuvenation' through supplements often relies on murine model data that has not been confirmed in human clinical trials.

    Findings #10

  • Dietary patterns and behavioral interventions are supported mostly by associative data or small-scale pilot studies.

    Findings #3, #7

  • Pharmacological weight loss intervention shown to reduce weight but fail to translate into improved IVF live birth rates.

    Findings

Node lineage & crossover disciplines

Parent lineage, active node, direct child sub-branches, and associated crossover disciplines across the Tree of Knowledge.

Hierarchy:
Natural & Life SciencesMedicine, Health & LongevityReproductive Medicine & Human FertilityClinical Nutrition and Assisted Reproductive Technology OutcomesAdiposity and Reproductive OutcomesAntioxidant Supplementation ProtocolsDietary Pattern InterventionsMetabolic Health and Embryo MorphokineticsNutritional Status and Oocyte Quality
+ Associated nodes:
Clinical Efficacy & Obstetric Outcomes (intersects) Developmental Competence of Non-2PN Zygotes (intersects) Ovarian Tissue Cryopreservation and Autotransplantation (intersects) Reproductive Medicine & Human Fertility (intersects)
  • + intersects Clinical Efficacy & Obstetric Outcomes — Shared mechanisms, study designs, or quantitative benchmarks between Clinical Efficacy & Obstetric Outcomes and Clinical Nutrition and Assisted Reproductive Technology Outcomes.
  • + intersects Developmental Competence of Non-2PN Zygotes — Shared mechanisms, study designs, or quantitative benchmarks between Clinical Nutrition and Assisted Reproductive Technology Outcomes and Developmental Competence of Non-2PN Zygotes.
  • + intersects Ovarian Tissue Cryopreservation and Autotransplantation — Shared mechanisms, study designs, or quantitative benchmarks between Clinical Nutrition and Assisted Reproductive Technology Outcomes and Ovarian Tissue Cryopreservation and Autotransplantation.
  • + intersects Reproductive Medicine & Human Fertility — Shared mechanisms, study designs, or quantitative benchmarks between Clinical Nutrition and Assisted Reproductive Technology Outcomes and Reproductive Medicine & Human Fertility.

Branches

AI Tree OrganiserExpand Clinical Nutrition and Assisted Reproductive Technology Outcomes

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Primary indexed sources (103)

Primary scientific literature, systematic reviews, and clinical trial registrations indexed for this branch.

  1. Endometriosis and Oocyte Quality: Morphological Alterations, Developmental Competence, and Modifiable Strategies for Reproductive Longevity — Martina Contestabile, Ilaria Marzi, Calogero Mangione et al. Cells, 2026, unknown, 11 citations · DOI: 10.3390/cells15030296
  2. Endometrial Microbiome and Implantation: From Basic Knowledge to Clinical Medicine — Daiki Hiratsuka, Mitsunori Matsuo, Yasushi Hirota Reproductive Medicine and Biology, 2026, expert opinion, 6 citations · DOI: 10.1002/rmb2.70040
  3. Next-Generation Dietary Antioxidants in Women’s Reproductive Health: Mechanisms, Reproductive Outcomes, and Therapeutic Potential — Abidur Rahman, Maroua Jalouli, Mohammed Mousa Al-Zharani et al. Antioxidants, 2026, expert opinion, 5 citations · DOI: 10.3390/antiox15030319
  4. Nutrition, Gut–Brain Axis and Cognitive Health: The Probiotics–Walnut Paradigm — Hanane Moummou, Ilyass Britel IntechOpen eBooks, 2026, expert opinion, 1 citations · DOI: 10.5772/intechopen.1014012
  5. Endometrial receptivity failure in assisted reproduction: immune-cellular niches, mechanistic evidence, and translational boundaries — Yuhang Zhang, Yi Zhu, Zhipeng Li et al. Frontiers in Immunology, 2026, expert opinion · DOI: 10.3389/fimmu.2026.1942809
  6. Modification effect of multiple gestation on the relationship between maternal body mass index and miscarriage in frozen-thawed embryo transfer: a retrospective cohort study. — Luo Z, Wang L, Zhao Z et al. Reproductive biology and endocrinology : RB&E, 2026, cohort · DOI: 10.1186/s12958-026-01586-1
  7. Effect of Comprehensive Spa Rehabilitation on Female Infertility: A Clinical Study in Adult Women (Infertility-Spa) Institute of Spa and Balneology, public research institution, 2026, rct
  8. Fertility and Polycystic Ovary Syndrome Assistance Publique - Hôpitaux de Paris, 2026, cohort
  9. Antioxidants in male infertility: from empirical supplementation to phenotype directed therapy — Mohammad Ishraq Zafar, Mengyuan Qu Frontiers in Endocrinology, 2026, unknown · DOI: 10.3389/fendo.2026.1971018
  10. The impact of the endometrial microbiome on IVF outcomes – current evidence — Anna Malczyk, Damian Zienkiewicz, Gabriela Makulec et al. Journal of Education Health and Sport, 2026, systematic review · DOI: 10.12775/jehs.2026.92.72390
  11. Sperm, Exposure and Endocrine Disruptors Million Marker Wellness, Inc., 2026, rct
  12. Mitochondrial Quality Control in PMOS/PCOS: A Review of Mechanisms, Biomarkers and Therapeutic Opportunities — Yusuf Aliyu Munir, Suleiman Hayatulah Aliyu, Ismail Salisu et al. UMYU Scientifica, 2026, unknown · DOI: 10.56919/usci.2654.005
  13. Clinical applications of digital twin technology in In Vitro Fertilisation — David B. Olawade, Oluwadamilola Racheal Abe, Kelechi Elizabeth Nwazuo et al. Journal of Gynecology Obstetrics and Human Reproduction, 2026, unknown · DOI: 10.1016/j.jogoh.2026.103235
  14. Early Prevention and Precision Management of Female Fertility Decline Peking University Third Hospital, 2026, rct
  15. Myo-Inositol Alone Versus Myo-Inositol Plus Alpha-Lactalbumin in Women With Polycystic Ovary Syndrome Quaid-e-Azam Medical College, 2026, rct
  16. Gamified Healthy Lifestyle Training in Women Undergoing Assisted Reproductive Treatment Marmara University, 2026, rct
  17. Varicocelectomy versus antioxidant therapy in infertile men with isolated asthenozoospermia: Comparative outcomes and predictors of treatment success — Mohammed Saber‐Khalaf, Atef Fathi, Mohamad AlaaEldein Elsuity et al. Arab Journal of Urology, 2026, unknown · DOI: 10.1080/20905998.2026.2737575
  18. Oocyte and dietary supplements: a mini review — Hao Chen, Shuoqi Wang, Meiying Song et al. Frontiers in Cell and Developmental Biology, 2025, systematic review, 9 citations · DOI: 10.3389/fcell.2025.1619758
  19. Global Andrology Forum Clinical Guidelines on Antioxidant Use in the Treatment of Male Infertility — Ashok Kumar Agarwal, Taymour Mostafa, Manaf Al Hashimi et al. The World Journal of Men s Health, 2025, guideline, 7 citations · DOI: 10.5534/wjmh.250290
  20. Uterine Microbiota and Bisphenols: Novel Influencers in Reproductive Health — Dafne Castellanos‐Ruiz, J. Gerardo Ojeda-Borbolla, Olga V. Ruiz-García et al. Journal of Xenobiotics, 2025, expert opinion, 6 citations · DOI: 10.3390/jox15010026
  21. The role of dysbiosis in shaping host immunity in endometrial cancer development — Wiktoria Wierzbińska, Olga Kuźmycz, Aleksandra Kowalczyk et al. Frontiers in Immunology, 2025, expert opinion, 2 citations · DOI: 10.3389/fimmu.2025.1627285
  22. Causes and Treatments of Recurrent Implantation Failure: A Systematic Review and Meta-Analysis — Carlo Bulletti, Anja Bisgaard Pinborg, Jason M. Franasiak et al. F1000Research, 2025, systematic review, 2 citations · DOI: 10.12688/f1000research.170152.1
  23. Impact of Obesity on In Vitro Fertilization (IVF) Outcomes: A Systematic Review. — Boddeti S, Noor K, Ansar M et al. Cureus, 2025, systematic review, 1 citations · DOI: 10.7759/cureus.90695
  24. O-009 OvoVid Phase 2: Role of micronutrients and probiotics supplementation on reproductive outcomes in an oocyte donation program: multicentric, double-blind, randomized, controlled trial — Stefania Maggi, Silvia Bontá, R Rodriguez et al. Human Reproduction, 2025, rct, 1 citations · DOI: 10.1093/humrep/deaf097.009
  25. Frame Support Study Inception Fertility Research Institute, LLC, 2025, rct
  26. Liraglutide Treatment in Obese Infertile PCOS Women Peking University Third Hospital, 2025, rct
  27. Lifestyle Intervention to Improve Twin Pregnancy Outcomes Universitaire Ziekenhuizen KU Leuven, 2025, rct
  28. The Effect of Mindfulness-Based Lifestyle Support Program on Infertile Women Dokuz Eylul University, 2025, rct
  29. Dietary Intervention to Improve Fertility in Women With Endometriosis Undergoing IVF Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 2025, rct
  30. Chapter VI: The Role Of Serotonin On The Gut-Brain Axis — Esra Aslan, Nuray Bostancıeri, Çiğdem Karaca et al. 2025, unknown · DOI: 10.55094/hp.556.c18
  31. Understanding Cycles to Improve Women's Health University Hospital, Montpellier, 2025, cohort
  32. A Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese University of Bonn, 2025, rct
  33. Molecular mechanisms of aging and anti-aging strategies — Yumeng Li, Xutong Tian, Juyue Luo et al. Cell Communication and Signaling, 2024, expert opinion, 296 citations · DOI: 10.1186/s12964-024-01663-1
  34. Current Status and Future Prospects of Stem Cell Therapy for Infertile Patients with Premature Ovarian Insufficiency — Hye Kyeong Kim, Tae Jin Kim Biomolecules, 2024, expert opinion, 38 citations · DOI: 10.3390/biom14020242
  35. Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age — Kuan‐Hao Tsui, Chia‐Jung Li, Li‐Te Lin Reproductive Biology and Endocrinology, 2024, cohort, 34 citations · DOI: 10.1186/s12958-024-01311-w
  36. Nutritional and exercise interventions to improve conception in women suffering from obesity and distinct nosological entities — Evdoxia Gitsi, Sarantis Livadas, Georgia Argyrakopoulou Frontiers in Endocrinology, 2024, 12 citations · DOI: 10.3389/fendo.2024.1426542
  37. Taurine, alpha lipoic acid and vitamin B6 ameliorate the reduced developmental competence of immature mouse oocytes exposed to methylglyoxal. — Mokhtari S, Mahdavi AH, Jafarpour F et al. Scientific reports, 2024, 10 citations · DOI: 10.1038/s41598-024-66785-5
  38. Normal weight obesity is associated with lower AFC and adverse IVF outcomes — Yangcheng Yao, Wenjuan Liu, Xiqian Zhang et al. Frontiers in Endocrinology, 2024, 9 citations · DOI: 10.3389/fendo.2024.1332995
  39. Adherence to dietary recommendations mediates the effect of affective temperaments on infertility treatment outcomes — Georgina Szabó, Judit Szigeti F., Miklós Sipos et al. Scientific Reports, 2024, 4 citations · DOI: 10.1038/s41598-024-63343-x
  40. The Impact of Lifestyle Intervention on Weight and Fertility in Obese Males Third Affiliated Hospital of Zhengzhou University, 2024, rct
  41. Factors Influencing the Maturation and Developmental Competence of Yak (Bos grunniens) Oocytes In Vitro — Luoyu Mo, Jun Ma, Yan Xiong et al. Genes, 2023, 17 citations · DOI: 10.3390/genes14101882
  42. Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients — Tansu Küçük, Pınar Erol Horozal, Asena Karakulak et al. Journal of Assisted Reproduction and Genetics, 2023, 13 citations · DOI: 10.1007/s10815-023-02847-3
  43. Association between preconception anti-androgen therapy and pregnancy outcomes of patients with PCOS: A prospective cohort study. — Zhang X, Miao H, Zhou J et al. Frontiers in endocrinology, 2023, 5 citations · DOI: 10.3389/fendo.2023.1109861
  44. IMPACT OF FETAL CANNABINOID EXPOSURE ON GUT-BRAIN AXIS DEVELOPMENT — Sunil, Maria MacSphere (McMaster University), 2023 · DOI: 10.71548/12231
  45. The Role of Microbiota in the Immunopathogenesis of Endometrial Cancer — Małgorzata Sobstyl, Peet Brecht, Anna Sobstyl et al. International Journal of Molecular Sciences, 2022, expert opinion, 59 citations · DOI: 10.3390/ijms23105756
  46. Effects of preconception weight loss after lifestyle intervention on fertility outcomes and pregnancy complications — Annemieke Hoek, Zheng Wang, Anne M. van Oers et al. Fertility and Sterility, 2022, meta analysis, 56 citations · DOI: 10.1016/j.fertnstert.2022.07.020
  47. Female dietary patterns and outcomes of in vitro fertilization (IVF): a systematic literature review — Elizabeth A. Sanderman, Sydney K. Willis, Lauren Anne Wise Nutrition Journal, 2022, systematic review, 42 citations · DOI: 10.1186/s12937-021-00757-7
  48. AAV-vector based gene therapy for mitochondrial disease: progress and future perspectives — Allison Rose Hanaford, Yoon‐Jae Cho, Hiroyuki Nakai Orphanet Journal of Rare Diseases, 2022, 23 citations · DOI: 10.1186/s13023-022-02324-7
  49. Preconception weight loss improves fertility and maternal outcomes in obese mice — Natassia Rodrigo, Hui Chen, Carol A Pollock et al. Journal of Endocrinology, 2022, 17 citations · DOI: 10.1530/joe-21-0399
  50. Dietary Antioxidants in the Treatment of Male Infertility: Counteracting Oxidative Stress — Elizabeth Torres-Arce, Barbara Vizmanos-Lamotte, Nancy Babió et al. Biology, 2021, unknown, 67 citations · DOI: 10.3390/biology10030241
  51. Maternal obesity and developmental programming of neuropsychiatric disorders: An inflammatory hypothesis — Jonathan M. Davis, Erik Mire Brain and Neuroscience Advances, 2021, expert opinion, 40 citations · DOI: 10.1177/23982128211003484
  52. Effect of Orlistat on Live Birth Rate in Overweight or Obese Women Undergoing IVF-ET: A Randomized Clinical Trial — Ze Wang, Junli Zhao, Xiang Ma et al. The Journal of Clinical Endocrinology & Metabolism, 2021, rct, 31 citations · DOI: 10.1210/clinem/dgab340
  53. The association between Vitamin D and clinical IVF outcomes, and the in vitro effects of Vitamin D on granulosa cell steroidogenesis and metabolism — Nikita L. Walz eSpace (Curtin University), 2021
  54. Dietary knowledge, attitudes and practices of pregnant and postpartum Sub-Saharan African immigrants in Finland — Johanna Walker UEF eRepo (University of Eastern Finland), 2021
  55. PROspective Study of Mothers' and Infants' Social and Epidemiologic Determinants of Health Northwestern University, 2021, cohort
  56. Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis — Mohammed Iddir, Alex Brito O, Giulia Dingeo et al. Nutrients, 2020, expert opinion, 786 citations · DOI: 10.3390/nu12061562
  57. The Interplay Between Reproductive Tract Microbiota and Immunological System in Human Reproduction — Salwan Al‐Nasiry, Elena Ambrosino, Melissa Schlaepfer et al. Frontiers in Immunology, 2020, expert opinion, 196 citations · DOI: 10.3389/fimmu.2020.00378
  58. Oxidative Stress in Male Infertility: Causes, Effects in Assisted Reproductive Techniques, and Protective Support of Antioxidants — Jordi Ribas‐Maynou, Marc Yeste Biology, 2020, expert opinion, 95 citations · DOI: 10.3390/biology9040077
  59. Therapeutic Approaches to Treat Mitochondrial Diseases: “One-Size-Fits-All” and “Precision Medicine” Strategies — Emanuela Bottani, Costanza Lamperti, Alessandro Prigione et al. Pharmaceutics, 2020, expert opinion, 82 citations · DOI: 10.3390/pharmaceutics12111083
  60. Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos — Maria Cristina Budani, Gian Mario Tiboni Antioxidants, 2020, expert opinion, 68 citations · DOI: 10.3390/antiox9070612
  61. IVF outcomes in patients with a history of bariatric surgery: a multicenter retrospective cohort study — Veronika Grzegorczyk-Martin, Thomas Fréour, A De Bantel Finet et al. Human Reproduction, 2020, cohort, 55 citations · DOI: 10.1093/humrep/deaa208
  62. Mechanisms and dynamics of mitochondrial disease stress responses : special emphasis on FGF21 — Saara Forsström Työväentutkimus Vuosikirja, 2020
  63. Internet-based Intervention to Promote a Healthy Lifestyle on the Reproductive Parameters of Overweight and Obese Women Cardenal Herrera University, 2020, rct
  64. Effect of different levels of weight loss on clinical outcomes in obese women with polycystic ovary syndrome underwent assisted reproduction — Li Y, Hu S, He F et al. Research Square, 2020, unknown · DOI: 10.21203/rs.2.24111/v1
  65. OR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized Trial — Legro R, Hansen K, Diamond M et al. Journal of the Endocrine Society, 2020
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